Regulated expression of the Ras effector Rin1 in forebrain neurons
| dc.contributor.author | Dzudzor, B. | |
| dc.contributor.author | Huynh, L. | |
| dc.contributor.author | Thai, M. | |
| dc.contributor.author | Bliss, J.M. | |
| dc.contributor.author | Nagaoka, Y. | |
| dc.contributor.author | Wang, Y. | |
| dc.contributor.author | Ch'ng, T.H. | |
| dc.contributor.author | Jiang, M. | |
| dc.contributor.author | Martin, K.C. | |
| dc.contributor.author | Colicelli, J. | |
| dc.date.accessioned | 2012-05-18T11:01:09Z | |
| dc.date.accessioned | 2017-10-19T12:00:08Z | |
| dc.date.available | 2012-05-18T11:01:09Z | |
| dc.date.available | 2017-10-19T12:00:08Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | The Ras effector Rin1 is induced concomitant with synaptogenesis in forebrain neurons, where it inhibits fear conditioning and amygdala LTP. In epithelial cells, lower levels of Rin1 orchestrate receptor endocytosis. A 945 bp Rin1 promoter fragment was active in hippocampal neurons and directed accurate tissue-specific and temporal expression in transgenic mice. Regulated expression in neurons and epithelial cells was mediated in part by Snail transcriptional repressors: mutation of a conserved Snail site increased expression and endogenous Snai1 was detected at the Rin1 promoter. We also describe an element closely related to, but distinct from, the consensus site for REST, a master repressor of neuronal genes. Conversion to a consensus REST sequence reduced expression in both cell types. These results provide insight into regulated expression of a neuronal Ras effector, define a promoter useful in telencephalic neuron studies, and describe a novel REST site variant directing expression to mature neurons. | en_US |
| dc.identifier.citation | Mol Cell Neurosci. 43(1): 108-16 | en_US |
| dc.identifier.uri | http://197.255.68.203/handle/123456789/1554 | |
| dc.language.iso | en | en_US |
| dc.publisher | Mol Cell Neurosci. | en_US |
| dc.title | Regulated expression of the Ras effector Rin1 in forebrain neurons | en_US |
| dc.type | Article | en_US |