Cervical Human Papillomavirus Prevalence, Genotypes, and Associated Risk Factors among Female Sex Workers in Greater Accra, Ghana
| dc.contributor.author | Adams, A.R. | |
| dc.contributor.author | Nortey, P.A. | |
| dc.contributor.author | Dortey, B.A. | |
| dc.contributor.author | Asmah, R.H. | |
| dc.contributor.author | Wiredu, E.K. | |
| dc.date.accessioned | 2019-12-05T12:10:58Z | |
| dc.date.available | 2019-12-05T12:10:58Z | |
| dc.date.issued | 2019-06-02 | |
| dc.description | Research Article | en_US |
| dc.description.abstract | Cervical cancer is a largely preventable disease mediated by persistent infectionwith high-riskHuman Papillomaviruses (Hr-HPV). There are now three approved vaccines against themost common HPV genotypes. In Ghana,mortality due to cervical cancer is on the rise, due to the absence of an organized and effective cervical cancer prevention and control program. Data on circulatingHPV genotypes is important for studying the likely impact of mass introduction of HPV vaccination of the female population before sexual debut. High HPV prevalence has been reported in Female Sex Workers (FSWs), who constitute an important active group for maintenance of HPV in the population.This study was conducted to determine the size of HPV prevalence in this group and to provide information for future assessment of the impact of vaccine introduction in the country.We conducted a cross-sectional study where the snowballing technique was used to identify and select FSW’s ≥18 years, operating within suburbs of Greater Accra Region (GAR). A risk factor assessment interview was conducted and cervical swabs were collected for HPV-DNA detection and genotyping by Nested Multiplex PCR. Hundred participants, age ranging from 18 to 45 years, median 24 years, were studied.The prevalence of Cervical HPV was 26%. Eleven genotypes were detected comprising 9 high-risk in order of decreasing prevalence HPV-16 (8%), HPV-35 (5%), HPV-33/39/-68 (3%), HPV-52/51/59 (2%) and HPV-18 (1%) and 2 Low-risk types, HPV-42(3%), and HPV-43 (1%).Three women had HPV types that could not be genotyped by our method. Oral contraceptives use was associated with a reduced chance of HPV infection (P=0.002; OR=0.19, 95% CI 0.07-0.54).This study found a high HPV prevalence among FSWs in the GAR. A high number of Hr-HPV genotypes seen are vaccine preventable, providing additional compelling argument for implementing a national cervical cancer prevention plan including vaccination | en_US |
| dc.identifier.other | https://doi.org/10.1155/2019/8062176 | |
| dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/34036 | |
| dc.language.iso | en | en_US |
| dc.publisher | Journal of Oncology | en_US |
| dc.relation.ispartofseries | 2019; | |
| dc.subject | Genotypes | en_US |
| dc.subject | Cervical cancer | en_US |
| dc.subject | high-riskHuman Papillomaviruses (Hr-HPV). | en_US |
| dc.subject | HPV vaccination | en_US |
| dc.title | Cervical Human Papillomavirus Prevalence, Genotypes, and Associated Risk Factors among Female Sex Workers in Greater Accra, Ghana | en_US |
| dc.type | Article | en_US |