Metabolism of (-)-(S)-nicotine in the isolated perfused rabbit lung.
| dc.contributor.author | Aislaitner, G. | |
| dc.contributor.author | Bello, A. | |
| dc.contributor.author | Tan, S.C. | |
| dc.contributor.author | Hutt, A.J. | |
| dc.contributor.author | Marriott, C. | |
| dc.contributor.author | Gorrod, J.W. | |
| dc.date.accessioned | 2013-06-28T09:51:03Z | |
| dc.date.accessioned | 2017-10-16T11:36:39Z | |
| dc.date.available | 2013-06-28T09:51:03Z | |
| dc.date.available | 2017-10-16T11:36:39Z | |
| dc.date.issued | 1997 | |
| dc.description.abstract | The metabolism of (-)-(S)-nicotine has been investigated following intratracheal administration to the recirculating perfused rabbit lung model. The metabolic products present in the perfusate were identified by co-chromatography (HPLC and GC) with authentic standards and quantified by HPLC. After the 180 min perfusion period, nicotine was found to be metabolically transformed to cotinine (33.7%), 3-hydroxycotinine (10.4%), cotinine-1-N-oxide (3.4%) and nicotine-1'-N-oxide (14.4%). Norcotinine, nornicotine, 3-pyridyl-4-oxo-N-methylbutyramide and an uncharacterised metabolite were also detected in low amounts. Following the perfusion experiment, part of the lung tissue was homogenised in the presence of [14C]-sodium cyanide. Subsequent analysis of the homogenates indicated the formation of 2'-cyanonicotine, 1'-cyanomethylnornicotine and the diastereoisomeric 5'-cyanonicotines. | en_US |
| dc.identifier.citation | 1. Aislaitner, G., Bello, A., Tan, S. C., Hutt, A. J., Marriott, C., & Gorrod, J. W. (1997). Metabolism of (-)-(S)-nicotine in the isolated perfused rabbit lung. European Journal of Drug Metabolism and Pharmacokinetics, 22(4), 395-402. | en_US |
| dc.identifier.uri | http://197.255.68.203/handle/123456789/4269 | |
| dc.language.iso | en | en_US |
| dc.title | Metabolism of (-)-(S)-nicotine in the isolated perfused rabbit lung. | en_US |
| dc.type | Article | en_US |