Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
dc.contributor.advisor | ||
dc.contributor.author | Haiman, C. A. | |
dc.contributor.author | Chen, G. K. | |
dc.contributor.author | Tettey, Y. | |
dc.contributor.author | Strom, S. S. | |
dc.contributor.author | Berndt, S. I. | |
dc.contributor.author | Kittles, R. A. | |
dc.contributor.author | Isaacs, W.B. | |
dc.contributor.author | Ingles, S.A. | |
dc.contributor.author | Stanford, J.L. | |
dc.contributor.author | Diver, W.R. | |
dc.contributor.author | Witte, J.S. | |
dc.contributor.author | Hsing, A.W. | |
dc.contributor.author | Nemesure, B. | |
dc.contributor.author | Rebbeck, T.R. | |
dc.contributor.author | Cooney, K.A. | |
dc.contributor.author | Xu, J. | |
dc.contributor.author | Kibel, A.S. | |
dc.contributor.author | Hu, J.J. | |
dc.contributor.author | John, E.M. | |
dc.contributor.author | Gueye, S.M. | |
dc.contributor.author | Watya, S. | |
dc.contributor.author | Signorello, L.B. | |
dc.contributor.author | Hayes, R.B. | |
dc.contributor.author | Wang, Z. | |
dc.contributor.author | Yeboah, E. | |
dc.contributor.author | Tettey, Y. | |
dc.contributor.author | Cai, Q. | |
dc.contributor.author | Kolb, S. | |
dc.contributor.author | Ostrander, E.A. | |
dc.contributor.author | Zeigler-Johnson, C. | |
dc.contributor.author | Yamamura, Y. | |
dc.contributor.author | Neslund-Dudas, C. | |
dc.contributor.author | Haslag-Minoff, J. | |
dc.contributor.author | Wu, W. | |
dc.contributor.author | Thomas, V. | |
dc.contributor.author | Allen, G.O. | |
dc.contributor.author | Murphy, A. | |
dc.contributor.author | Chang, B.L. | |
dc.contributor.author | Zheng, S.L. | |
dc.contributor.author | Leske, M.C. | |
dc.contributor.author | Wu, S.Y. | |
dc.contributor.author | Ray, A.M. | |
dc.contributor.author | Hennis, A.J. | |
dc.contributor.author | Thun, M.J. | |
dc.contributor.author | Carpten, J. | |
dc.contributor.author | Casey, G. | |
dc.contributor.author | Carter, E.N. | |
dc.contributor.author | Duarte, E.R. | |
dc.contributor.author | Xia, L.Y. | |
dc.contributor.author | Sheng, X. | |
dc.contributor.author | Wan, P. | |
dc.contributor.author | Pooler, L.C. | |
dc.contributor.author | Cheng, I. | |
dc.contributor.author | Monroe, K.R. | |
dc.contributor.author | Schumacher, F. | |
dc.contributor.author | Le Marchand, L. | |
dc.contributor.author | Kolonel, L.N. | |
dc.contributor.author | Van Den Berg, D. | |
dc.contributor.author | Chanock, S.J. | |
dc.contributor.author | Stram, D.O. | |
dc.contributor.author | Henderson, B.E. | |
dc.date.accessioned | 2013-06-21T15:46:55Z | |
dc.date.accessioned | 2017-10-19T12:42:11Z | |
dc.date.available | 2013-06-21T15:46:55Z | |
dc.date.available | 2017-10-19T12:42:11Z | |
dc.date.issued | 2011-05-22 | |
dc.description.abstract | In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations. | en_US |
dc.identifier.citation | 14. Haiman, C. A., Chen, G. K., Tettey, Y., Strom, S. S., Berndt, S. I., Kittles, R. A., . . . Henderson, B. E. (2011). Genome-wide association study of prostate cancer in men of african ancestry identifies a susceptibility locus at 17q21. Nature Genetics, 43(6), 570-573. | en_US |
dc.identifier.uri | http://197.255.68.203/handle/123456789/3881 | |
dc.title | Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. | en_US |