Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.

Haiman, C. A.; Chen, G. K.; Tettey, Y.; Strom, S. S.; Berndt, S. I.; Kittles, R. A.; Isaacs, W.B.; Ingles, S.A.; Stanford, J.L.; Diver, W.R.; Witte, J.S.; Hsing, A.W.; Nemesure, B.; Rebbeck, T.R.; Cooney, K.A.; Xu, J.; Kibel, A.S.; Hu, J.J.; John, E.M.; Gueye, S.M.; Watya, S.; Signorello, L.B.; Hayes, R.B.; Wang, Z.; Yeboah, E.; Cai, Q.; Kolb, S.; Ostrander, E.A.; Zeigler-Johnson, C.; Yamamura, Y.; Neslund-Dudas, C.; Haslag-Minoff, J.; Wu, W.; Thomas, V.; Allen, G.O.; Murphy, A.; Chang, B.L.; Zheng, S.L.; Leske, M.C.; Wu, S.Y.; Ray, A.M.; Hennis, A.J.; Thun, M.J.; Carpten, J.; Casey, G.; Carter, E.N.; Duarte, E.R.; Xia, L.Y.; Sheng, X.; Wan, P.; Pooler, L.C.; Cheng, I.; Monroe, K.R.; Schumacher, F.; Le Marchand, L.; Kolonel, L.N.; Van Den Berg, D.; Chanock, S.J.; Stram, D.O.; Henderson, B.E.

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.

Date

2011-05-22

Authors

Abstract

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

Citation

14. Haiman, C. A., Chen, G. K., Tettey, Y., Strom, S. S., Berndt, S. I., Kittles, R. A., . . . Henderson, B. E. (2011). Genome-wide association study of prostate cancer in men of african ancestry identifies a susceptibility locus at 17q21. Nature Genetics, 43(6), 570-573.