Elevated levels of IL-10 and G-CSF associated with asymptomatic malaria in pregnant women

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dc.contributor.authorWilson, N.O.
dc.contributor.authorBythwood, T.
dc.contributor.authorSolomon, W.
dc.contributor.authorJolly, P.
dc.contributor.authorYatich, N.
dc.contributor.authorJiang, Y.
dc.contributor.authorShuaib, F.
dc.contributor.authorAdjei, A.A.
dc.contributor.authorAnderson, W.
dc.contributor.authorStiles, J.K.
dc.date.accessioned2019-02-18T16:44:06Z
dc.date.available2019-02-18T16:44:06Z
dc.date.issued2010-07
dc.description.abstractIn sub-Saharan Africa, approximately 30 million pregnant women are at risk of contracting malaria annually. Nearly 36 of healthy pregnant women receiving routine antenatal care tested positive for Plasmodium falciparum HRP-II antigen in Ghana. We tested the hypothesis that asymptomatic HRP II positive pregnant women expressed a unique Th1 and Th2 phenotype that differs from healthy controls. Plasma from healthy (n = 15) and asymptomatic (n = 25) pregnant women were evaluated for 27 biomarkers (IL-1b, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL- 17, Eotaxin, bFGF-2, G-CSF, GM-CSF, IFN-γ, IP-10, MCP-1, MIP-1α, MIP-1β, PDGF-bb, RANTES, TNF, and VEGF) associated with Th1 and Th2 cytokine homeostasis. IL-10 and G-CSF levels were elevated in the asymptomatic group when compared with the healthy group (P =.031 and.041, resp.). The median ratios of IL-1β:5, IL-1β:10, IL-1β:G-CSF, IL-1β:Eotaxin, IL-12:G-CSF, IL-15:10, IL-17:G-CSF, IL-17:Eotaxin, TNF:IL-4, TNF:IL-5, and TNF:G-CSF were significantly different among the two groups. Thus, asymptomatic malaria carriage may be linked to circulating levels of IL-10 and G-CSF. Copyright © 2010 Nana O. Wilson et al.en_US
dc.identifier.otherdoi: 10.1155/2010/317430
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/27621
dc.language.isoenen_US
dc.publisherInfectious Diseases in Obstetrics and Gynecologyen_US
dc.titleElevated levels of IL-10 and G-CSF associated with asymptomatic malaria in pregnant womenen_US
dc.typeArticleen_US

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