Glucose-6-phosphate dehydrogenase deficiency genotypes and allele frequencies in the Kavango and Zambezi regions of northern Namibia

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dc.contributor.authorAbabio, G
dc.contributor.authorHaiyambo, D.H.
dc.contributor.authorIlunga, A.
dc.contributor.authorNangombe, R.
dc.contributor.authorHatuikulipi, T.
dc.contributor.authorAleksenko, L.
dc.contributor.authorMisihairabgwi, J.
dc.contributor.authorUusiku, P.
dc.contributor.authorPernica, J.M.
dc.contributor.authorGreco, B.
dc.contributor.authorQuaye, I.K.
dc.date.accessioned2019-09-30T11:28:05Z
dc.date.available2019-09-30T11:28:05Z
dc.date.issued2019-04-09
dc.descriptionResearch Articleen_US
dc.description.abstractBackground: Namibia has made significant gains in the fight against malaria, with a target of elimination by 2023. We examined the genotype and allele frequencies of glucose-6-phosphate dehydrogenase (G6PD) deficiency to inform decisions on primaquine use, as we recently detected clusters of Plasmodium ovale curtisi in Kavango. Methods: A multistaged cross-sectional sampling method was used to enrol 212 children 2–9 y of age from schools and clinics in the Okavango and Zambezi regions of northern Namibia. Genotypes for the 202 G→A and 376 A→G mutations were assigned by polymerase chain reaction restriction fragment length polymorphism. Results: Of the 212 subjects enrolled, genotypes were available for 210, made up of 61 males and 149 females. G6PD-deficient males (hemizygotes) and females (homozygotes) constituted 3.27% (2/61) and 0.0% (0/149), respectively. Female heterozygotes (AA− and BA−) constituted 10.07% (15/149), while G6PD wild-type males (with A or B haplotype) and females (with AA, BB or AB haplotypes) consisted of 96.72% (59/61) and 89.93% (134/149), respectively. The A−, A and B allele frequencies were 0.0474, 0.3036 and 0.6490, respectively. Hardy–Weinberg equilibrium tests for female genotype frequencies did not show deviation (p=0.29). Conclusions: The frequency of G6PD deficiency alleles in males in the Kavango and Zambezi regions of northern Namibia constitute 3.27%, a first report to inform policy on primaquine role out.en_US
dc.description.sponsorshipMerck KGaA, Darmstadt, Germany grant R025).en_US
dc.identifier.otherdoi: 10.1093/trstmh/trz035
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/32347
dc.language.isoenen_US
dc.publisherTransactions of the Royal Society of Tropical Medicine and Hygieneen_US
dc.relation.ispartofseries113;
dc.subjectG6PDd allelesen_US
dc.subjectGenotypesen_US
dc.subjectKavangoen_US
dc.subjectNamibiaen_US
dc.subjectPrimaquineen_US
dc.subjectZambezien_US
dc.titleGlucose-6-phosphate dehydrogenase deficiency genotypes and allele frequencies in the Kavango and Zambezi regions of northern Namibiaen_US
dc.typeArticleen_US

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