Browsing by Author "Tetteh, D."
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Item Development of porous ceramic bodies from kaolin deposits for industrial applications(2012) Efavi, J.K.; Damoah, L.N.W.; Bensah, D.Y.; Arhin, D.D.; Tetteh, D.The possibility of fabricating porous ceramic bodies from kaolin using maize, rice, saw-dust, charcoal, millet and Styrofoam as pore formers have been explored in this work after chemical analysis of two kaolin deposits located at Assin Fosu and Saltpond both in the Central Region of Ghana.Batch formulations of the Kaolin samples were formed into greenbodies and fired to 1400°C at a controlled rate. Samples with charcoal, millet, sawdust, maize and rice pore formers showed severe surface cracks and low thermal shock after firing. A control batch process using Styrofoam exhibited uniform surface characteristics with pores, high strength, thermal stability and no surface cracks thereby confirming the viability of the process modules. Apparent porosity as high as 38% has been calculated.Item Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia(BMC Medical Genetics, 2019-11-27) Ababio, G.K.; Adu-Bonsaffoh, K.; Abindau, E.; Narh, G.; Tetteh, D.; Botchway, F.; Morvey, D.; Neequaye, J.; Quaye, I.K.Background: Factor V Leiden polymorphism is a well-recognized genetic factor in the etiology of preeclampsia. Considering that Ghana is recording high incidence of preeclampsia, we examined if factor V Leiden is a contributory factor to its development and pregnancy outcomes. Methods: STROBE consensus checklist was adopted to recruit eighty-one (81) consenting subjects after ethical clearance. Subjects were followed up till delivery to obtain outcomes of PE. Routine blood chemistry and proteinuria were done on all samples. Factor V Leiden was characterized by polymerase chain reaction and restriction fragment length polymorphism (RFLP). The data was captured as protected health information (PHI) and analyzed with SPSS version 22. Results: Overall allelic frequencies found in FVL exon 10 were 0.67 and 0.33 for G and A alleles respectively. The FVL mutation was more in PE and hypertensive patients. Increased white blood cells, increased uric acid and a three – fold increment of AST / ALT ratio was observed in PE cases when stratified by FVL exons (exon 8 and 10). Significant differences were also observed between FVL and age, systolic blood pressure (SBP), diastolic blood pressure (DBP), liver enzymes, white blood cells (wbc), hemoglobin levels. Conclusion: FVL mutation allele frequency was 0.33, a first report. The mutation was associated with increased uric acid, liver enzymes and blood cell indices suggestive of acute inflammation.Item Occupational Hearing Loss among Workers Exposed to Industrial Chemicals and Noise: A Study in a Paint Company and Among Automobile Sprayers in Ghana(University of Ghana, 2014-07) Tetteh, D.; Amedofu, G.; Anim-Sampong, S.; University of Ghana, College of Health Sciences , School of Biomedical and Allied Health Sciences , Department of Audiology, Speech and LanguageBackground: Occupational hearing loss is a general term used to describe hearing loss that occurs in work environments. Noise and industrial chemicals such as organic solvents are two main toxic acoustic disturbance and substances that can have adverse effects on the auditory system and consequently induce hearing loss. This is corroborated by experimental studies on both animal and human which confirm ototoxic effects of industrial organic solvents and noise. Worldwide, several industries employ industrial chemicals in the manufacture of paints. In Ghana, there are several work environment which employ organic solvents in the manufacture and use of paints. Presently, published studies have not been done in Ghana on the ototoxicity of industrial chemicals and noise on hearing loss. Aim: This study aims to evaluate the effect of occupational exposure to noise and industrial chemicals on hearing loss in a paint company and among automobile sprayers. This study is aimed at creating awareness of the effects of industrial chemicals and noise exposure on the peripheral auditory system of humans and find if significant occupational hearing loss exist among workers exposed to industrial chemicals and noise. Methodology: A cross-sectional study comprising case-control sample of 115 workers was selected purposively and conveniently from a paint company and five automobile garages who were either exposed to or not exposed to industrial chemical or and noise. The procedure adopted included noise survey, industrial chemical survey, case history, otoscopy, tympanometry and standard pure-tone audiometry. Results: The odds of hearing loss found in the group exposed to both noise and solvents was 1.096 (95% CI.0.340-3.532) higher than those in the noise only group (0.062 odds, 95% CI.0.016-1.108) as compared to the control group. Conclusion: This suggests that there is an association between occupational exposure to both industrial chemicals and noise with hearing loss. Keywords: ototoxicity, ototraumatic, chemical induced- hearing loss, noise induced- hearing loss