Browsing by Author "Owusu-Adjei, S."

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In vitro response of P.falciparum to chloroquine, amodiaquine, quinine and sulfadoxine/pryrimethamine in Ghana.
(Ghana Medical Journal, 1989-12) Akanmori, B.D.; Afari, E.A.; Nakano, T.; Ofori-Adjei, D.; Gyan, B.; Owusu-Adjei, S.; Adjei, A.A.
In Vitro asexual parasite sensitivity to chloroquine, amodiaquine, quinine, and sulfadoxine/pyrimethamine (SDZ/PYR) combination was determined for Plasmodium falciparum isolates from children in three schools at Nima (Urban), Madina (Peri urban) and Gomoa Fetteh (Rural), during the rainy season. Chloroquine resistance was present in 625% of children at Nima, 69.6% (23136) of children at Madina and 50% (16132) of those in Gomoa Fetteh. Resistance of P. falciparum to amodiaquine was recorded in 30% (6/20),35.7% (5/14) and 12.5% (1/8) of children in Nima, Madina and Gomoa Fetteh respectively. In addition parasite resistance to SDX/PYR was found in children in Nima, Madina and in one child at Gomoa Fetteh. Resistance to both chloroquine and amodiaquine was present in 3 children at Nima, 5 at Madina and in a single child at Gomoa Fettteh. Resistance to both chloroquine and SDX/PYR and to Amodiaquine and SDXIPYR was restricted to only Nima (2/15, 1/15) .and Madina 3/14, 2/15). There was no resistance to quinine in any of the areas studied. A progressive increase in minimum inhibitory concentrations (IC9O) for chloroquine was observed from Nima and Madina to rural Gomma Fetteh. Similarly, IC90 for amodiaquine was highest in Madina. The presence of multiple-drug resistant P. falciparum in these children represents a challenge to the control and management of falciparum malaria and this data serves as a baseline for monitoring any changes in parasite sensitivity to antimalarial drugs in the study areas
In vivo and in vitro sensibility of P.falciparum to chloroquine in three communities in Ghana
(Ghana Medical Journal, 1989-12) Afari, E.A.; Akanmori, B.D.; Nakano, T.; Ofori-Adjei, D.; Gyan, B.; Owusu-Adjei, S.; Adjei, A.A.
In vivo and in vitro P. falciparum asexual parasite sensitivity to chloroquine tests were performed in three schools at Nima, Madina and Gomoo Fet· teh - urban, periurban and rural communities respectively in Ghana during the rainy season from June to October, 1988. Of the 144 in Vivo tests performed 116(80.6%) were sensitive to chloroquine and 28(19.4%) showed resistance to chloroquine at RI (3.5%) and RII (15.9%) levels. Fifty-four out of the 92 (.58.7%) successful in vitro tests carried out Concurrently with the in vivo test were resistant to chloroquine. P. falciparum resistance to chloroquine waS emerged in Ghana and what is urgently required now is intensive and sustained education on judicious selection and proper use of available antimalarials and the promotion of research activities that may provide more data for sound drug policy for miliaria treatment in Ghana.
Some Demographic Characteristics of two rural communities in Southern Ghana
(Ghana Medical Journal, 1988-09) Afari, E.A.; Nakano, T.; Owusu-Adjei, S.
A study of the demographic characteristics of two rural villages in Southern Ghana in 1987 showed an average rate of natural population increase of 3.8 percent compared to 3.2 per cent recorded nationally (1984 census data). The crude death rates and Infant Mortality rates were far lower than the figures usually quoted, although the birth rate was similar to the national average. It is suggested that if such rates exist in similar villages in Ghana, then official projections are underestimates and will have grave consequences on national development plans. It appears that Primary Health Care (PHC) has succeeded in reducing deaths but has not affected births. Family planning must, therefore, receive more attention.