In vivo and in vitro sensibility of P.falciparum to chloroquine in three communities in Ghana
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Date
1989-12
Journal Title
Journal ISSN
Volume Title
Publisher
Ghana Medical Journal
Abstract
In vivo and in vitro P. falciparum asexual parasite
sensitivity to chloroquine tests were performed in
three schools at Nima, Madina and Gomoo FetĀ·
teh - urban, periurban and rural communities
respectively in Ghana during the rainy season from
June to October, 1988.
Of the 144 in Vivo tests performed 116(80.6%)
were sensitive to chloroquine and 28(19.4%)
showed resistance to chloroquine at RI (3.5%)
and RII (15.9%) levels. Fifty-four out of the 92
(.58.7%) successful in vitro tests carried out Concurrently with the in vivo test were resistant to
chloroquine. P. falciparum resistance to chloroquine waS emerged in Ghana and what is urgently
required now is intensive and sustained education
on judicious selection and proper use of available
antimalarials and the promotion of research activities that may provide more data for sound drug
policy for miliaria treatment in Ghana.
Description
Journal Article
Keywords
P. falciparum, Chloroquine, In vivo, In vitro sensitivity, Resistance