In vitro response of P.falciparum to chloroquine, amodiaquine, quinine and sulfadoxine/pryrimethamine in Ghana.
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Date
1989-12
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Journal ISSN
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Publisher
Ghana Medical Journal
Abstract
In Vitro asexual parasite sensitivity to chloroquine,
amodiaquine, quinine, and sulfadoxine/pyrimethamine (SDZ/PYR) combination was determined for Plasmodium falciparum
isolates from children in three schools at Nima
(Urban), Madina (Peri urban) and Gomoa Fetteh
(Rural), during the rainy season. Chloroquine
resistance was present in 625% of children at
Nima, 69.6% (23136) of children at Madina and
50% (16132) of those in Gomoa Fetteh. Resistance
of P. falciparum to amodiaquine was
recorded in 30% (6/20),35.7% (5/14) and 12.5%
(1/8) of children in Nima, Madina and Gomoa
Fetteh respectively. In addition parasite resistance
to SDX/PYR was found in children in Nima,
Madina and in one child at Gomoa Fetteh. Resistance
to both chloroquine and amodiaquine was
present in 3 children at Nima, 5 at Madina and in
a single child at Gomoa Fettteh. Resistance to
both chloroquine and SDX/PYR and to Amodiaquine
and SDXIPYR was restricted to only Nima
(2/15, 1/15) .and Madina 3/14, 2/15). There was no
resistance to quinine in any of the areas studied.
A progressive increase in minimum inhibitory concentrations (IC9O) for chloroquine was observed
from Nima and Madina to rural Gomma Fetteh.
Similarly, IC90 for amodiaquine was highest in
Madina. The presence of multiple-drug resistant
P. falciparum in these children represents a challenge to the control and management of falciparum
malaria and this data serves as a baseline
for monitoring any changes in parasite sensitivity
to antimalarial drugs in the study areas
Description
Journal Article
Keywords
Chloroquine, Quinine, Sulfadoxine/Pyrimethamine, P. falciparum, In vitro sensitivity