Acute P. falciparum malaria induces a loss of CD28- T IFN-γ producing cells

Simple item page
dc.contributor.authorKemp, K.
dc.contributor.authorAkanmori, B.D.
dc.contributor.authorKurtzhals, J.A.L.
dc.contributor.authorAdabayeri, V.
dc.contributor.authorGoka, B.Q.
dc.contributor.authorHviid, L.
dc.date.accessioned2019-03-04T08:45:22Z
dc.date.available2019-03-04T08:45:22Z
dc.date.issued2002-11
dc.description.abstractP. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-γ and IL-4 by CD28- and CD28+ T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-γ producing CD28- T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.en_US
dc.identifier.otherVol. 24(11-12): pp 545-8
dc.identifier.otherDOI: 10.1046/j.1365-3024.2002.00599.x
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/28489
dc.language.isoenen_US
dc.publisherParasite Immunologyen_US
dc.subjectApoptosisen_US
dc.subjectCD28en_US
dc.subjectCytokinesen_US
dc.subjectMalariaen_US
dc.subjectT-cellsen_US
dc.titleAcute P. falciparum malaria induces a loss of CD28- T IFN-γ producing cellsen_US
dc.typeArticleen_US

Files

License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.6 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Immunology Department