Acute P. falciparum malaria induces a loss of CD28- T IFN-γ producing cells

dc.contributor.author	Kemp, K.
dc.contributor.author	Akanmori, B.D.
dc.contributor.author	Kurtzhals, J.A.L.
dc.contributor.author	Adabayeri, V.
dc.contributor.author	Goka, B.Q.
dc.contributor.author	Hviid, L.
dc.date.accessioned	2019-03-04T08:45:22Z
dc.date.available	2019-03-04T08:45:22Z
dc.date.issued	2002-11
dc.description.abstract	P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-γ and IL-4 by CD28- and CD28+ T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-γ producing CD28- T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.	en_US
dc.identifier.other	Vol. 24(11-12): pp 545-8
dc.identifier.other	DOI: 10.1046/j.1365-3024.2002.00599.x
dc.identifier.uri	http://ugspace.ug.edu.gh/handle/123456789/28489
dc.language.iso	en	en_US
dc.publisher	Parasite Immunology	en_US
dc.subject	Apoptosis	en_US
dc.subject	CD28	en_US
dc.subject	Cytokines	en_US
dc.subject	Malaria	en_US
dc.subject	T-cells	en_US
dc.title	Acute P. falciparum malaria induces a loss of CD28- T IFN-γ producing cells	en_US
dc.type	Article	en_US

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