Acute P. falciparum malaria induces a loss of CD28- T IFN-γ producing cells
dc.contributor.author | Kemp, K. | |
dc.contributor.author | Akanmori, B.D. | |
dc.contributor.author | Kurtzhals, J.A.L. | |
dc.contributor.author | Adabayeri, V. | |
dc.contributor.author | Goka, B.Q. | |
dc.contributor.author | Hviid, L. | |
dc.date.accessioned | 2019-03-04T08:45:22Z | |
dc.date.available | 2019-03-04T08:45:22Z | |
dc.date.issued | 2002-11 | |
dc.description.abstract | P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-γ and IL-4 by CD28- and CD28+ T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-γ producing CD28- T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria. | en_US |
dc.identifier.other | Vol. 24(11-12): pp 545-8 | |
dc.identifier.other | DOI: 10.1046/j.1365-3024.2002.00599.x | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/28489 | |
dc.language.iso | en | en_US |
dc.publisher | Parasite Immunology | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | CD28 | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Malaria | en_US |
dc.subject | T-cells | en_US |
dc.title | Acute P. falciparum malaria induces a loss of CD28- T IFN-γ producing cells | en_US |
dc.type | Article | en_US |
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