Acute P. falciparum malaria induces a loss of CD28- T IFN-γ producing cells
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Date
2002-11
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Publisher
Parasite Immunology
Abstract
P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-γ and IL-4 by CD28- and CD28+ T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-γ producing CD28- T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.
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Keywords
Apoptosis, CD28, Cytokines, Malaria, T-cells