Association between global DNA methylation (LINE-1) and occupational particulate matter exposure among informal electronic-waste recyclers in Ghana
dc.contributor.author | Issah, I. | |
dc.contributor.author | Arko-Mensah, J. | |
dc.contributor.author | Rozek, L.S. | |
dc.contributor.author | Rentschler, K. | |
dc.contributor.author | Agyekum, T.P. | |
dc.contributor.author | Dwumoh, D. | |
dc.contributor.author | Batterman, S. | |
dc.contributor.author | Robins, T.G. | |
dc.contributor.author | Fobil, J.N. | |
dc.date.accessioned | 2022-01-06T12:40:08Z | |
dc.date.available | 2022-01-06T12:40:08Z | |
dc.date.issued | 2021 | |
dc.description | Research Article | en_US |
dc.description.abstract | This study examined the associations between PM (2.5 and 10) and global DNA methylation among 100 e-waste workers and 51 non-e-waste work ers serving as controls. Long interspersed nucleotide repetitive elements 1 (LINE-1) was measured by pyrosequencing. Personal PM2.5 and PM10 were measured over a 4-hour work-shift using real-time particulate moni tors incorporated into a backpack . Linear regression models were used to assess the association between PM and LINE-1 DNA methylation. The concentrations of PM2.5 and PM10 were significantly higher among the e-waste workers than the controls (77.32 vs 34.88, p < 0.001 and 210.21 vs 121.92, p < 0.001, respectively). PM2.5 exposure was associated with increased LINE-1 CpG2 DNA methylation (β = 0.003; 95% CI; 0.001, 0.006; p = 0.022) but not with the average of all 4 CpG sites of LINE-1. In summary, high levels of PM2.5 exposure was associated with increased levels of global DNA methylation in a site-specific manner. | en_US |
dc.identifier.other | https://doi.org/10.1080/09603123.2021.1969007 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/37499 | |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis Group | en_US |
dc.subject | DNA methylation | en_US |
dc.subject | LINE-1 | en_US |
dc.subject | PM2.5 | en_US |
dc.subject | PM10 | en_US |
dc.subject | e-waste | en_US |
dc.subject | e-waste workers | en_US |
dc.title | Association between global DNA methylation (LINE-1) and occupational particulate matter exposure among informal electronic-waste recyclers in Ghana | en_US |
dc.type | Article | en_US |
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