Association between global DNA methylation (LINE-1) and occupational particulate matter exposure among informal electronic-waste recyclers in Ghana

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dc.contributor.authorIssah, I.
dc.contributor.authorArko-Mensah, J.
dc.contributor.authorRozek, L.S.
dc.contributor.authorRentschler, K.
dc.contributor.authorAgyekum, T.P.
dc.contributor.authorDwumoh, D.
dc.contributor.authorBatterman, S.
dc.contributor.authorRobins, T.G.
dc.contributor.authorFobil, J.N.
dc.date.accessioned2022-01-06T12:40:08Z
dc.date.available2022-01-06T12:40:08Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractThis study examined the associations between PM (2.5 and 10) and global DNA methylation among 100 e-waste workers and 51 non-e-waste work ers serving as controls. Long interspersed nucleotide repetitive elements 1 (LINE-1) was measured by pyrosequencing. Personal PM2.5 and PM10 were measured over a 4-hour work-shift using real-time particulate moni tors incorporated into a backpack . Linear regression models were used to assess the association between PM and LINE-1 DNA methylation. The concentrations of PM2.5 and PM10 were significantly higher among the e-waste workers than the controls (77.32 vs 34.88, p < 0.001 and 210.21 vs 121.92, p < 0.001, respectively). PM2.5 exposure was associated with increased LINE-1 CpG2 DNA methylation (β = 0.003; 95% CI; 0.001, 0.006; p = 0.022) but not with the average of all 4 CpG sites of LINE-1. In summary, high levels of PM2.5 exposure was associated with increased levels of global DNA methylation in a site-specific manner.en_US
dc.identifier.otherhttps://doi.org/10.1080/09603123.2021.1969007
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37499
dc.language.isoenen_US
dc.publisherTaylor & Francis Groupen_US
dc.subjectDNA methylationen_US
dc.subjectLINE-1en_US
dc.subjectPM2.5en_US
dc.subjectPM10en_US
dc.subjecte-wasteen_US
dc.subjecte-waste workersen_US
dc.titleAssociation between global DNA methylation (LINE-1) and occupational particulate matter exposure among informal electronic-waste recyclers in Ghanaen_US
dc.typeArticleen_US

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