Common variants at 11p13 are associated with susceptibility to tuberculosis

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dc.contributor.authorThye, T.
dc.contributor.authorOwusu-Dabo, E.
dc.contributor.authorVannberg, F.O.
dc.contributor.authorvan Crevel, R.
dc.contributor.authorCurtis, J.
dc.contributor.authorSahiratmadja, E.
dc.contributor.authorBalabanova, Y.
dc.contributor.authorEhmen, C.
dc.contributor.authorMuntau, B.
dc.contributor.authorRuge, G.
dc.contributor.authorSievertsen, J.
dc.contributor.authorGyapong, J.
dc.contributor.authorNikolayevskyy, V.
dc.contributor.authorHill, P.C.
dc.contributor.authorSirugo, G.
dc.contributor.authorDrobniewski, F.
dc.contributor.authorvan de Vosse, E.
dc.contributor.authorNewport, M.
dc.contributor.authorAlisjahbana, B.
dc.contributor.authorNejentsev, S.
dc.contributor.authorOttenhoff, T.H.
dc.contributor.authorHill, A.V.
dc.contributor.authorHorstmann, R.D.
dc.contributor.authorMeyer, C.G.
dc.date.accessioned2012-09-13T11:34:38Z
dc.date.accessioned2017-10-16T12:22:23Z
dc.date.available2012-09-13T11:34:38Z
dc.date.available2017-10-16T12:22:23Z
dc.date.issued2012
dc.description.abstractAfter imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10−9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10−11.en_US
dc.identifier.citationNature Genetics. 2012 Feb 5. doi: 10.1038/ng.1080en_US
dc.identifier.urihttp://197.255.68.203/handle/123456789/1838
dc.language.isoenen_US
dc.publisherNature Geneticsen_US
dc.subjectTuberculosisen_US
dc.titleCommon variants at 11p13 are associated with susceptibility to tuberculosisen_US
dc.typeArticleen_US

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