Common variants at 11p13 are associated with susceptibility to tuberculosis
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Genetics
Abstract
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10−9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10−11.
Description
Keywords
Tuberculosis
Citation
Nature Genetics. 2012 Feb 5. doi: 10.1038/ng.1080