Tenofovir‑associated renal toxicity in a cohort of HIV infected patients in Ghana
| dc.contributor.author | Nartey, E.T. | |
| dc.contributor.author | Tetteh, R.A. | |
| dc.contributor.author | Yankey, B.A. | |
| dc.contributor.author | Mantel‑Teeuwisse, A.K. | |
| dc.contributor.author | Leufkens, H.G.M. | |
| dc.contributor.author | Dodoo, A.N.O. | |
| dc.contributor.author | Lartey, M. | |
| dc.date.accessioned | 2019-09-10T14:51:00Z | |
| dc.date.available | 2019-09-10T14:51:00Z | |
| dc.date.issued | 2019-07-09 | |
| dc.description | Research Article | en_US |
| dc.description.abstract | Objective: Tenofovir disoproxil fumarate (TDF) is a nucleotide analogue recommended in international HIV treatment guidelines. Purpose of this study was to estimate the long term effects of TDF on renal profile in a cohort of HIV patients in Ghana. Three hundred (300) consecutive HIV-positive patients who initiated TDF-based antiretroviral treatment in 2008 at the Korle-Bu Teaching Hospital were sampled. Creatinine clearance (CrCl) was calculated using the Cockcroft-Gault equation at baseline and renal impairment was defined as CrCl values of 30.0–49.9 mL/min (moderate renal impairment) and < 30 mL/min (severe renal impairment) as per institutional guidelines for renal function test. Results: Median follow up time was 2.9 years (IQR 2.3–3.4 years). At study endpoint, 63 participants (21.0% [95% CI 6.5–26.1]) recorded CrCl rate below 50 mL/min indicating incident renal impairment, made up of 18.3% moderate renal impairment and 2.3% severe renal impairment. Factors associated with incidence of renal impairment were increasing age, decrease in creatinine clearance rate at baseline, WHO HIV stage III/IV and participants with BMI of < 18.5 kg/m2. Patients with identified renal impairment risk factors at ART initiation should be targeted and monitored effectively to prevent renal | en_US |
| dc.identifier.other | https://doi.org/10.1186/s13104-019-4454-2 | |
| dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/32115 | |
| dc.language.iso | en | en_US |
| dc.publisher | BMC Research Notes | en_US |
| dc.relation.ispartofseries | ;2019 | |
| dc.subject | Tenofovir disoproxil fumarate | en_US |
| dc.subject | Renal dysfunction | en_US |
| dc.subject | Creatinine clearance | en_US |
| dc.subject | HIV | en_US |
| dc.subject | ART | en_US |
| dc.title | Tenofovir‑associated renal toxicity in a cohort of HIV infected patients in Ghana | en_US |
| dc.type | Article | en_US |