Tenofovir‑associated renal toxicity in a cohort of HIV infected patients in Ghana
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Date
2019-07-09
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Research Notes
Abstract
Objective: Tenofovir disoproxil fumarate (TDF) is a nucleotide analogue recommended in international HIV treatment
guidelines. Purpose of this study was to estimate the long term effects of TDF on renal profile in a cohort of HIV
patients in Ghana. Three hundred (300) consecutive HIV-positive patients who initiated TDF-based antiretroviral treatment
in 2008 at the Korle-Bu Teaching Hospital were sampled. Creatinine clearance (CrCl) was calculated using the
Cockcroft-Gault equation at baseline and renal impairment was defined as CrCl values of 30.0–49.9 mL/min (moderate
renal impairment) and < 30 mL/min (severe renal impairment) as per institutional guidelines for renal function test.
Results: Median follow up time was 2.9 years (IQR 2.3–3.4 years). At study endpoint, 63 participants (21.0% [95% CI
6.5–26.1]) recorded CrCl rate below 50 mL/min indicating incident renal impairment, made up of 18.3% moderate
renal impairment and 2.3% severe renal impairment. Factors associated with incidence of renal impairment were
increasing age, decrease in creatinine clearance rate at baseline, WHO HIV stage III/IV and participants with BMI
of < 18.5 kg/m2. Patients with identified renal impairment risk factors at ART initiation should be targeted and monitored
effectively to prevent renal
Description
Research Article
Keywords
Tenofovir disoproxil fumarate, Renal dysfunction, Creatinine clearance, HIV, ART