Longitudinal control of blood pressure among a cohort of Ghanaians with hypertension: A multicenter, hospital-based study
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Date
2020-03-04
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Clinical Hypertension
Abstract
There are limited data on factors associated with longitudinal control of blood pressure
(BP) among Ghanaians on antihypertensive treatment. We sought to evaluate
associations between prospective BP control and 24 putative factors within
socio-demographic, biological, and organizational domains. This is a cohort study
involving 1867 (65%) adults with hypertension and 1006 (35%) with both hypertension
and diabetes mellitus at five public hospitals. Clinic BP was measured every
2 months for 18 months of follow-up. A multivariate logistic regression analysis was
fitted via generalized linear mixed models to identify factors associated with clinic
BP ≥ 140/90 mm Hg at each clinic visit during follow-up. Mean age of study participants
was 58.9 ± 16.6 years and 76.8% were females. Proportions with controlled BP
increased from 46.3% at baseline to 59.8% at month 18, P < .0001. Eight factors with
adjusted OR (95% CI) associated prospectively with uncontrolled BP were male gender:
1.37 (1.09-1.72), secondary education: 1.32 (1.00-1.74), non-adherence to antihypertensive
treatment: 1.03 (1.00-1.06), fruit intake: 0.94 (0.89-1.00), duration of
hypertension diagnosis: 1.01 (1.00-1.02), hypertension with diabetes mellitus: 2.05 (1.72-2.46), number of antihypertensive medications: 1.63 (1.49-1.79), and estimated
glomerular filtration rate (mL/min rise): 0.82 (0.76-0.89). Interventions aimed at addressing
modifiable factors associated with poorly controlled BP would be critical in
prevention of cardiovascular diseases among Ghanaians
Description
Research Article
Keywords
blood pressure (BP), hypertension, secondary education, Clinic BP
Citation
Sarfo FS, Mobula L, Plange-Rhule J, et al. Longitudinal control of blood pressure among a cohort of Ghanaians with hypertension: A multicenter, hospital-based study. J Clin Hypertens. 2020;22:949–958. https://doi. org/10.1111/jch.13873