Some effects of the medicinal plant kalanchoe pinnata.

Abstract

The hepatoprotective and choleretic effects of Kalanchoe pinnata syrup prepared from its extract were studied using the rat model of toxic hepatitis, produced by the administration of the hepatotoxic compound 50% solution of carbon tetrachloride. The syrup was introduced in a dosage of 30 mg/kg. After the administration of syrup Kalanchoe (per os) in rats with toxic hepatitis, the following enzymes considered to be informative during toxic hepatitis were determined: alanine transaminase, alkaline phosphatase and triglycerides. The cholagogic (choleretic) effect was determined by cannulating the common bile duct and determining the amount and content of bile produced within three hours. The antimicrobial activity of the syrup was determined using a microbial inhibition assay. The Kalanchoe syrup was seen to normalize the level of alaninetransaminase, alkaline phosphatase and triglycerides in the animals with toxic hepatitis and increase the secretion of bile with the contents of cholesterine. Acids and the cholato-cholesteric coefficient in the bile remained unchanged. The syrup was found to react with some strains of Staphylococcus aureus and Escherchia coli. This finding demonstrates the hepatoprotective, choleretic and antimicrobial activity of syrup Kalanchoe.