Short-term treatment outcomes in human immunodeficiency virus type-1 and hepatitis B virus co-infections
| dc.contributor.author | Sagoe, K.W.C. | |
| dc.contributor.author | Duedu, K.O. | |
| dc.contributor.author | Ziga, F. | |
| dc.contributor.author | Agyei, A.A. | |
| dc.contributor.author | Adiku, T.K. | |
| dc.contributor.author | Lartey, M. | |
| dc.contributor.author | Mingle, J.A.A. | |
| dc.contributor.author | Arens, M. | |
| dc.date.accessioned | 2016-06-02T06:04:42Z | |
| dc.date.available | 2016-06-02T06:04:42Z | |
| dc.date.issued | 2016-06-02 | |
| dc.date.updated | 2016-06-02T06:04:48Z | |
| dc.description.abstract | Abstract Background Co-infection of HIV with HBV is common in West Africa but little information is available on the effects of HBV on short-term therapy for HIV patients. A 28 day longitudinal study was conducted to examine short-term antiretroviral therapy (ART) outcomes in HIV infected individuals with HBV co-infection. Methods Plasma from 18 HIV infected individuals co-infected with HBV and matched controls with only HIV infection were obtained at initiation, and 7 and 28 days after ART. HIV-1 viral load changes were monitored. Clinical and demographic data were also obtained from patient folders, and HIV-1 drug resistance mutation and subtype analysis performed. Results The presence of HBV co-infection did not significantly affect HIV-1 viral load changes within 7 or 28 days. The CD4+ counts on the other hand of patients significantly affected the magnitude of HIV-1 viral load decline after 7 days (ρ = −0.441, p = 0.040), while the pre-ART HIV-1 VL (ρ = 0.844, p = <0.001) and sex (U = 19.0, p = 0.020) also determined HIV-1 viral load outcomes after 28 days of ART. Even though the geometric sensitivity score of HIV-1 strains were influenced by the HIV-1 subtypes (U = 56.00; p = 0.036), it was not a confounder for ART outcomes. Conclusions There may be the need to consider the confounder effects of sex, pre-ART CD4+, and pre-ART HIV-1 viral load in the discourse on HIV and HBV co-infection. | |
| dc.identifier.citation | Annals of Clinical Microbiology and Antimicrobials. 2016 Jun 02;15(1):38 | |
| dc.identifier.uri | http://dx.doi.org/10.1186/s12941-016-0152-2 | |
| dc.identifier.uri | http://197.255.68.203/handle/123456789/8333 | |
| dc.language.rfc3066 | en | |
| dc.rights.holder | The Author(s) | |
| dc.title | Short-term treatment outcomes in human immunodeficiency virus type-1 and hepatitis B virus co-infections | |
| dc.type | Journal Article |