Impact of blood perilipin A levels on obesity and metabolic health

Abstract

Objective: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxida‑ tive damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health. Results: The participants in this study were 86 individuals with a mean age of 45.5±1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho=− 0.32, − 0.37, − 0.40, − 0.45, − 0.33 and − 0.29; p<0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio=6.22, CI=2.35–11.50, p<0.001). Our fndings underscore the important role of perilipin A proteins in metabolic health. Keyword