Impact of blood perilipin A levels on obesity and metabolic health
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
. BMC Research Notes
Abstract
Objective: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxida‑
tive damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood
and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they
relate to metabolic health.
Results: The participants in this study were 86 individuals with a mean age of 45.5±1.2 years. Multiple clinical and
metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely
associated with perilipin A levels (rho=− 0.32, − 0.37, − 0.40, − 0.45, − 0.33 and − 0.29; p<0.05 respectively).
Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds
ratio=6.22, CI=2.35–11.50, p<0.001). Our fndings underscore the important role of perilipin A proteins in metabolic
health.
Keyword
Description
Research Article
Keywords
Perilipin A, Obesity, Insulin resistance, Lipids