Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population

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dc.contributor.authorSchoenhard, J.A.
dc.contributor.authorAsselbergs, F.W.
dc.contributor.authorPoku, K.A.
dc.contributor.authorStocki, S.A.
dc.contributor.authorGordon, S.
dc.contributor.authorVaughan, D.E.
dc.contributor.authorBrown, N.J.
dc.contributor.authorMoore, J.H.
dc.contributor.authorWilliams, S.M.
dc.date.accessioned2019-04-12T11:14:26Z
dc.date.available2019-04-12T11:14:26Z
dc.date.issued2008-11
dc.description.abstractTissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) directly influence thrombus formation and degradation, and have been identified as risk factors for thromboembolic disease. Prior studies investigated determinants of t-PA and PAI-1 expression, but mainly in Caucasian subjects. The aim of this study was to identify the contributions of genetic and other factors to inter-individual variation in plasma levels of t-PA and PAI-1 in a large-scale population-based sample from urban West Africa. t-PA, PAI-1 and several demographic, anthropometric, and metabolic parameters were measured in 992 residents of Sunyani, the capital of the Brong-Ahafo region of Ghana. In addition, nine gene polymorphisms associated with components of the renin-angiotensin and fibrinolytic systems were determined. We found that BMI, systolic and diastolic blood pressure, total cholesterol, glucose, and triglycerides were all significant predictors of t-PA and PAI-1 in both females and males. In addition, a significant relationship was found between the PAI-1 4G/5G (rs1799768) polymorphism on PAI-1 levels in females, the TPA I/D (rs4646972) polymorphism on t-PA and PAI-1 in males, the renin (rs3730103) polymorphism on t-PA and PAI-1 in males, the ethanolamine kinase 2 (rs1917542) polymorphism on PAI-1 in males, and the renin (rs1464816) polymorphism on t-PA in females and on PAI-1 in males. This study of urban West Africans shows that t-PA and PAI-1 levels are determined by both genetic loci of the fibrinolytic and renin-angiotensin systems and other factors often associated with cardiovascular disease, and that genetic factors differ between males and females. © Springer-Verlag 2008.en_US
dc.identifier.otherVol.124(5): pp 479-88
dc.identifier.otherDOI: 10.1007/s00439-008-0573-x
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/29207
dc.language.isoenen_US
dc.publisherHuman Geneticsen_US
dc.titleMale-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian populationen_US
dc.typeArticleen_US

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