Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets

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dc.contributor.authorOsei-Safo, D.
dc.contributor.authorAmewu, R.K.
dc.contributor.authorSakyi, P.O.
dc.contributor.authoret al.
dc.date.accessioned2023-06-29T08:28:06Z
dc.date.available2023-06-29T08:28:06Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractAbstract: Cancer is a complex group of diseases initiated by abnormal cell division with the potential of spreading to other parts of the body. The advancement in the discoveries of omics and bio- and cheminformatics has led to the identification of drugs inhibiting putative targets including vascular endothelial growth factor (VEGF) family receptors, fibroblast growth factors (FGF), platelet derived growth factors (PDGF), epidermal growth factor (EGF), thymidine phosphorylase (TP), and neuropeptide Y4 (NY4), amongst others. Drug resistance, systemic toxicity, and drug ineffectiveness for various cancer chemo-treatments are widespread. Due to this, efficient therapeutic agents targeting two or more of the putative targets in different cancer cells are proposed as cutting edge treatments. Heterocyclic compounds, both synthetic and natural products, have, however, contributed immensely to chemotherapeutics for treatments of various diseases, but little is known about such compounds and their multimodal anticancer properties. A compendium of heterocyclic synthetic and natural product multitarget anticancer compounds, their IC50, and biological targets of inhibition are therefore presented in this review.en_US
dc.identifier.otherhttps://doi.org/10.3390/molecules26237134
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/39434
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectHomeostasisen_US
dc.subjectMetastasisen_US
dc.subjectAngiogenesisen_US
dc.subjectApoptosisen_US
dc.subjectVascularizationen_US
dc.subjectHeterocyclic compoundsen_US
dc.subjectMultiple biological targetsen_US
dc.titleSynthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targetsen_US
dc.typeArticleen_US

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