Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets
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Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Abstract: Cancer is a complex group of diseases initiated by abnormal cell division with the potential of spreading to other parts of the body. The advancement in the discoveries of omics and
bio- and cheminformatics has led to the identification of drugs inhibiting putative targets including vascular endothelial growth factor (VEGF) family receptors, fibroblast growth factors (FGF),
platelet derived growth factors (PDGF), epidermal growth factor (EGF), thymidine phosphorylase
(TP), and neuropeptide Y4 (NY4), amongst others. Drug resistance, systemic toxicity, and drug
ineffectiveness for various cancer chemo-treatments are widespread. Due to this, efficient therapeutic
agents targeting two or more of the putative targets in different cancer cells are proposed as cutting
edge treatments. Heterocyclic compounds, both synthetic and natural products, have, however,
contributed immensely to chemotherapeutics for treatments of various diseases, but little is known
about such compounds and their multimodal anticancer properties. A compendium of heterocyclic
synthetic and natural product multitarget anticancer compounds, their IC50, and biological targets of
inhibition are therefore presented in this review.
Description
Research Article
Keywords
Homeostasis, Metastasis, Angiogenesis, Apoptosis, Vascularization, Heterocyclic compounds, Multiple biological targets