The Effect of Croton Membranaceus on Dihydrotestosterone Levels in Blood and Its Synthesis by Prostatic 5α-Reductase in the Rat

dc.contributor.advisorAddy, M.E.
dc.contributor.authorAboagye, F.A.
dc.contributor.otherUniversity of Ghana, College of Basic and Applied Sciences, School of Biological Sciences, Department of Biochemistry, Cell and Molecular Biology
dc.date.accessioned2015-06-11T16:29:16Z
dc.date.accessioned2017-10-13T17:04:53Z
dc.date.available2015-06-11T16:29:16Z
dc.date.available2017-10-13T17:04:53Z
dc.date.issued1997-12
dc.description.abstractAlcoholic extract of Croton membranaceus Mull. Arg is used atthe Centre for Scientific Research into Plant Medicine at Mampong Akwapim to treat retention of urine due to benign prostatic hyperplasia (BPH). The effect of the extract on rat steroid 5areductase activity in invo was investigated using a radioimmunoassay technique to quantitate dihydrotestosterone (DHT) levels in blood. The effects of the extract and two unidentified alkaloidal isolates of the plant, provisionally referred to as CM-1 and CM-3, were investigated in vitro as potential inhibitors of 5α-reductase activity using a thin layer chromatographic technique to quantitate DHT formed from testosterone. The results show that the extract may not lower rat serum DHT levels significantly in vivo but both the extract and the isolated CM-1 inhibited the enzyme activity in vitro at the concentrations used. The other isolate, CM-3, did not inhibit the enzyme at the concentration used. The results obtained suggest that inhibition of 5a-reductase activity may not be the major mechanism by which the extract exerts its action in BPH patients.en_US
dc.format.extentvii,87p
dc.identifier.issn30692107859074
dc.identifier.urihttp://197.255.68.203/handle/123456789/6152
dc.language.isoen_USen_US
dc.publisherUniversity of Ghanaen_US
dc.rights.holderUniversity of Ghana
dc.titleThe Effect of Croton Membranaceus on Dihydrotestosterone Levels in Blood and Its Synthesis by Prostatic 5α-Reductase in the Raten_US
dc.typeThesisen_US

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