Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

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dc.contributor.authorThye, T.
dc.contributor.authorVannberg, F.O.
dc.contributor.authorWong, S.H.
dc.contributor.authorOwusu-Dabo, E.
dc.contributor.authorOsei, I.
dc.contributor.authorGyapong, J.
dc.contributor.authorSirugo, G.
dc.contributor.authorSisay-Joof, F.
dc.contributor.authorEnimil, A.
dc.contributor.authorChinbuah, M.A.
dc.contributor.authorFloyd, S.
dc.contributor.authorWarndorff, D.K.
dc.contributor.authorSichali, L.
dc.contributor.authorMalema, S.
dc.contributor.authorCrampin, A.C.
dc.contributor.authorNgwira, B.
dc.contributor.authorTeo, Y.Y.
dc.contributor.authorSmall, K.
dc.contributor.authorRockett, K.
dc.contributor.authorKwiatkowski, D.
dc.contributor.authorFine, P.E.
dc.contributor.authorHill, P.C.
dc.contributor.authorNewport, M.
dc.contributor.authorLienhardt, C.
dc.contributor.authorAdegbola, R.A.
dc.contributor.authorCorrah, T.
dc.contributor.authorZiegler, A.
dc.contributor.authorAfrican TB Genetics Consortium
dc.contributor.authorWellcome Trust Case Control Consortium
dc.contributor.authorMorris, A.P.
dc.contributor.authorMeyer, C.G.
dc.contributor.authorHorstmann, R.D.
dc.contributor.authorHill, A.V.
dc.date.accessioned2013-08-14T15:47:53Z
dc.date.accessioned2017-10-16T12:23:08Z
dc.date.available2013-08-14T15:47:53Z
dc.date.available2017-10-16T12:23:08Z
dc.date.issued2010-09
dc.description.abstractWe combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.en_US
dc.identifier.citationThye, T., Vannberg, F. O., Wong, S. H., Owusu-Dabo, E., Osei, I., Gyapong, J., ... & Hill, A. V. (2010). Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11. 2. Nature genetics, 42(9), 739-741.en_US
dc.identifier.issn15461718
dc.identifier.urihttp://197.255.68.203/handle/123456789/4305
dc.language.isoenen_US
dc.subjectEMTREE medical terms: article; case control study; chromosome 18; Gambia; gene linkage disequilibrium; gene locus; genetic association; genetic predisposition; genetics; Ghana; human; population genetics; risk; single nucleotide polymorphism; tuberculosisen_US
dc.subjectMeSH: Case-Control Studies; Chromosomes, Human, Pair 18; Gambia; Genetic Loci; Genetic Predisposition to Disease; Genetics, Population; Genome-Wide Association Study; Ghana; Humans; Linkage Disequilibrium; Odds Ratio; Polymorphism, Single Nucleotide; Tuberculosisen_US
dc.titleGenome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.en_US
dc.typeArticleen_US

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