Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
dc.contributor.author | Thye, T. | |
dc.contributor.author | Vannberg, F.O. | |
dc.contributor.author | Wong, S.H. | |
dc.contributor.author | Owusu-Dabo, E. | |
dc.contributor.author | Osei, I. | |
dc.contributor.author | Gyapong, J. | |
dc.contributor.author | Sirugo, G. | |
dc.contributor.author | Sisay-Joof, F. | |
dc.contributor.author | Enimil, A. | |
dc.contributor.author | Chinbuah, M.A. | |
dc.contributor.author | Floyd, S. | |
dc.contributor.author | Warndorff, D.K. | |
dc.contributor.author | Sichali, L. | |
dc.contributor.author | Malema, S. | |
dc.contributor.author | Crampin, A.C. | |
dc.contributor.author | Ngwira, B. | |
dc.contributor.author | Teo, Y.Y. | |
dc.contributor.author | Small, K. | |
dc.contributor.author | Rockett, K. | |
dc.contributor.author | Kwiatkowski, D. | |
dc.contributor.author | Fine, P.E. | |
dc.contributor.author | Hill, P.C. | |
dc.contributor.author | Newport, M. | |
dc.contributor.author | Lienhardt, C. | |
dc.contributor.author | Adegbola, R.A. | |
dc.contributor.author | Corrah, T. | |
dc.contributor.author | Ziegler, A. | |
dc.contributor.author | African TB Genetics Consortium | |
dc.contributor.author | Wellcome Trust Case Control Consortium | |
dc.contributor.author | Morris, A.P. | |
dc.contributor.author | Meyer, C.G. | |
dc.contributor.author | Horstmann, R.D. | |
dc.contributor.author | Hill, A.V. | |
dc.date.accessioned | 2013-08-14T15:47:53Z | |
dc.date.accessioned | 2017-10-16T12:23:08Z | |
dc.date.available | 2013-08-14T15:47:53Z | |
dc.date.available | 2017-10-16T12:23:08Z | |
dc.date.issued | 2010-09 | |
dc.description.abstract | We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low. | en_US |
dc.identifier.citation | Thye, T., Vannberg, F. O., Wong, S. H., Owusu-Dabo, E., Osei, I., Gyapong, J., ... & Hill, A. V. (2010). Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11. 2. Nature genetics, 42(9), 739-741. | en_US |
dc.identifier.issn | 15461718 | |
dc.identifier.uri | http://197.255.68.203/handle/123456789/4305 | |
dc.language.iso | en | en_US |
dc.subject | EMTREE medical terms: article; case control study; chromosome 18; Gambia; gene linkage disequilibrium; gene locus; genetic association; genetic predisposition; genetics; Ghana; human; population genetics; risk; single nucleotide polymorphism; tuberculosis | en_US |
dc.subject | MeSH: Case-Control Studies; Chromosomes, Human, Pair 18; Gambia; Genetic Loci; Genetic Predisposition to Disease; Genetics, Population; Genome-Wide Association Study; Ghana; Humans; Linkage Disequilibrium; Odds Ratio; Polymorphism, Single Nucleotide; Tuberculosis | en_US |
dc.title | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. | en_US |
dc.type | Article | en_US |