Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Thye, T.; Vannberg, F.O.; Wong, S.H.; Owusu-Dabo, E.; Osei, I.; Gyapong, J.; Sirugo, G.; Sisay-Joof, F.; Enimil, A.; Chinbuah, M.A.; Floyd, S.; Warndorff, D.K.; Sichali, L.; Malema, S.; Crampin, A.C.; Ngwira, B.; Teo, Y.Y.; Small, K.; Rockett, K.; Kwiatkowski, D.; Fine, P.E.; Hill, P.C.; Newport, M.; Lienhardt, C.; Adegbola, R.A.; Corrah, T.; Ziegler, A.; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Morris, A.P.; Meyer, C.G.; Horstmann, R.D.; Hill, A.V.

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Date

2010-09

Authors

Abstract

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Keywords

EMTREE medical terms: article; case control study; chromosome 18; Gambia; gene linkage disequilibrium; gene locus; genetic association; genetic predisposition; genetics; Ghana; human; population genetics; risk; single nucleotide polymorphism; tuberculosis, MeSH: Case-Control Studies; Chromosomes, Human, Pair 18; Gambia; Genetic Loci; Genetic Predisposition to Disease; Genetics, Population; Genome-Wide Association Study; Ghana; Humans; Linkage Disequilibrium; Odds Ratio; Polymorphism, Single Nucleotide; Tuberculosis

Citation

Thye, T., Vannberg, F. O., Wong, S. H., Owusu-Dabo, E., Osei, I., Gyapong, J., ... & Hill, A. V. (2010). Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11. 2. Nature genetics, 42(9), 739-741.