The burden of hospital acquired infections and antimicrobial resistance
| dc.contributor.author | Abban, M.K. | |
| dc.contributor.author | Ayerakwa, E.A. | |
| dc.contributor.author | Mosi, L. | |
| dc.contributor.author | Isawumi, A. | |
| dc.date.accessioned | 2023-10-19T10:52:45Z | |
| dc.date.available | 2023-10-19T10:52:45Z | |
| dc.date.issued | 2023 | |
| dc.description | Research Article | en_US |
| dc.description.abstract | The burden of Hospital care-associated infections (HCAIs) is becoming a global concern. This is compounded by the emergence of virulent and high-risk bacterial strains such as “ESKAPE” pathogens – (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species), especially within Intensive care units (ICUs) that house high-risk and immunocompromised patients. In this review, we discuss the contributions of AMR pathogens to the increasing burden of HCAIs and provide insights into AMR mechanisms, with a particular focus on last-resort antibiotics like polymyxins. We exten sively discuss how structural modifications of surface-membrane lipopolysaccharides and cationic interactions influence and inform AMR, and subsequent severity of HCAIs. We highlight some bacterial phenotypic survival mechanisms against polymyxins. Lastly, we discuss the emergence of plasmid-mediated resistance as a phenomenon making mitigation of AMR difficult, especially within the ICUs. This review provides a balanced perspective on the burden of HCAIs, associated pathogens, implication of AMR and factors influencing emerging AMR mechanisms. | en_US |
| dc.identifier.other | https://doi.org/10.1016/j.heliyon.2023.e20561 | |
| dc.identifier.uri | http://ugspace.ug.edu.gh:8080/handle/123456789/40451 | |
| dc.language.iso | en | en_US |
| dc.publisher | Heliyon | en_US |
| dc.subject | Hospital care-associated infections | en_US |
| dc.subject | Nosocomial infections | en_US |
| dc.subject | Antimicrobial resistance | en_US |
| dc.title | The burden of hospital acquired infections and antimicrobial resistance | en_US |
| dc.type | Article | en_US |