Community acquired urinary tract infections among adults in Accra, Ghana

dc.contributor.authorDayie, N.T.K.D
dc.contributor.authorDonkor, E.S.
dc.contributor.authorHorlortu, P.Z.
dc.contributor.authorObeng-Nkrumah, N.
dc.contributor.authorLabi, A.K.
dc.date.accessioned2019-09-24T11:41:47Z
dc.date.available2019-09-24T11:41:47Z
dc.date.issued2019-04-23
dc.descriptionResearch Articleen_US
dc.description.abstractBackground: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases encountered in clinical practice, and accounts for significant morbidity and high medical costs. To reduce its public health burden, there is the need for local research data to address aspects of prevention and management of UTI. The aim of this study was to investigate community-acquired UTI among adults in Accra, Ghana, including the risk factors, etiological agents, and antibiotic resistance. Methods: This was a cross-sectional study involving 307 patients clinically diagnosed with UTI at the Korle Bu and Mamprobi polyclinics in Accra. Urine specimens were collected from the study participants and analyzed by culture, microscopy, and dipstick. The bacterial isolates were identified using standard microbiological methods and tested against a spectrum of antibiotics by the Kirby Bauer method. Multidrug resistant Enterobacteriaceae isolates were screened for Extended Spectrum β-lactamase (ESBL) production by the double disc method, and isolates that tested positive were analyzed by Polymerase Chain Reaction for ESBL genes. Demographic information and clinical history of study participants were collected. Results: Based on the criteria for laboratory confirmed UTI, 31 (10.1%) of the 307 specimens were positive and the main risk factor of UTI among the study participants was pregnancy (P=0.02, OR=2.43). The most common uropathogen isolated was Escherichia coli (48.9%), followed by Klebseilla sp. (16.1%). Prevalence of resistance was highest for Piperacillin (87.1%) and Amoxicillin+Clavulanic Acid (87.1%) and lowest for Amikacin (12.9%). Prevalence of multidrug resistance among the uropathogens was 80.1% (25) and the most common ESBL gene detected was CTX-M-15. Conclusion: Pregnant women constitute the key risk population of UTI in Accra, while Amikacin remains a suitable drug for the treatment of febrile UTI. The high prevalence of multidrug resistance among the uropathogens highlights the need for surveillance of antimicrobial resistance among these pathogensen_US
dc.identifier.otherDOI https://doi.org/10.2147/IDR.S204880
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/32267
dc.language.isoenen_US
dc.publisherInfection and Drug Resistanceen_US
dc.relation.ispartofseries12;2019
dc.subjectExtended spectrum β-lactamasesen_US
dc.subjectMultidrug resistanceen_US
dc.subjectUrinary tract infectionen_US
dc.titleCommunity acquired urinary tract infections among adults in Accra, Ghanaen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
idr-204880-community-acquired-urinary-tract-infections-among-adults-in-.pdf
Size:
443.23 KB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.6 KB
Format:
Item-specific license agreed upon to submission
Description: