Elevated circulating IL-17 level is associated with inflammatory arthritis and disease activity: A meta-analysis

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dc.contributor.authorSam, N.B.
dc.contributor.authorZhang, X.
dc.contributor.authorYuan, Y.
dc.contributor.authorPan, Z.
dc.contributor.authorMa, Y.
dc.contributor.authorWu, M.
dc.contributor.authorYang, J.
dc.contributor.authorHan, R.
dc.contributor.authorChen, M.
dc.contributor.authorHu, X.
dc.contributor.authorLiu, R.
dc.contributor.authorXu, S.
dc.contributor.authorPan, F.
dc.date.accessioned2019-09-27T11:39:28Z
dc.date.available2019-09-27T11:39:28Z
dc.date.issued2019-06-29
dc.descriptionResearch Articleen_US
dc.description.abstractObjectives: Previous studies found that the interleukin (IL)-17 level was elevated in inflammatory arthritis, but results were inconsistent. This meta-analysis aimed to investigate the association of IL-17 cytokine with osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Methods: Relevant studies were searched using databases. Standardized mean difference (SMD) was calculated. Correlation coefficient was utilized to evaluate the relationship between IL-17 and disease activity of AS and RA. Subgroup analysis, sensitivity analysis and meta-regression were applied to explore the sources of heterogeneity. Results: 83 records were enrolled. The IL-17 level was elevated in AS (SMD=2.348, P < .001), RA (SMD=1.502, P < .001), PsA (SMD=1.710, P < .001) and OA (SMD=1.192, P=.016), and similar results occurred in subgroup analysis. Furthermore, the IL-17 level was positively associated with disease activity of AS and RA. Conclusion: Circulating IL-17 level is significantly elevated in inflammatory arthritis and is related to the disease activity of AS and RA, suggesting that it plays an important role in the pathogenesis and progression of inflammatory arthritis (especially in AS and RA).en_US
dc.description.sponsorshipNational Natural Science Foundation of China,Academic and Technical Leaders Foundation of Anhui Province (2017D140)en_US
dc.identifier.otherhttps://doi.org/10.1016/j.cca.2019.06.026
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/32328
dc.language.isoenen_US
dc.publisherClinica Chimica Actaen_US
dc.relation.ispartofseries496;2019
dc.subjectArthritisen_US
dc.subjectCytokinesen_US
dc.subjectInflammatory arthritisen_US
dc.subjectInterleukin-17en_US
dc.subjectIL-17en_US
dc.titleElevated circulating IL-17 level is associated with inflammatory arthritis and disease activity: A meta-analysisen_US
dc.typeArticleen_US

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