Undescribed sesquiterpenoids with NO production inhibitory activity from oleo-gum resin of Commiphora myrrha
dc.contributor.author | Zhang, B. | |
dc.contributor.author | Chao, W. | |
dc.contributor.author | Donkor, P.O. | |
dc.contributor.author | et al. | |
dc.date.accessioned | 2024-03-05T10:29:18Z | |
dc.date.available | 2024-03-05T10:29:18Z | |
dc.date.issued | 2024 | |
dc.description | Research Article | en_US |
dc.description.abstract | Six undescribed cadinane sesquiterpenoids (1− 6), two undescribed guaiane sesquiterpenoids (7− 8), and an undescribed germacrane sesquiterpenoid (9) were isolated from the oleo-gum resin of Commiphora myrrha. Their structures were determined by the analysis of 1D/2D NMR and HRESIMS data, as well as quantum chemical ECD and NMR calculations. All the sesquiterpenoids were evaluated for their NO production inhibitory activity in LPS-stimulated RAW 264.7 mouse monocyte-macrophages. The results revealed that commiphone A (1) and commipholide D (7) exhibited significant inhibitory effect on NO generation with IC50 values of 18.6 ± 2.0 and 37.5 ± 1.5 μM, respectively. Furthermore, 1 and 7 dose-dependently inhibited the mRNA expression of in flammatory cytokines IL-1β, IL-6 and TNF-α induced by LPS in the RAW264.7 cells, indicating that 1 and 7 possess potent anti-inflammatory activity in vitro. | en_US |
dc.identifier.other | https://doi.org/10.1016/j.phytochem.2024.114031 | |
dc.identifier.uri | http://ugspace.ug.edu.gh:8080/handle/123456789/41405 | |
dc.language.iso | en | en_US |
dc.publisher | Phytochemistry | en_US |
dc.subject | Commiphora myrrha | en_US |
dc.subject | Myrrh | en_US |
dc.subject | Burseraceae | en_US |
dc.title | Undescribed sesquiterpenoids with NO production inhibitory activity from oleo-gum resin of Commiphora myrrha | en_US |
dc.type | Article | en_US |
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