Undescribed sesquiterpenoids with NO production inhibitory activity from oleo-gum resin of Commiphora myrrha

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dc.contributor.authorZhang, B.
dc.contributor.authorChao, W.
dc.contributor.authorDonkor, P.O.
dc.contributor.authoret al.
dc.date.accessioned2024-03-05T10:29:18Z
dc.date.available2024-03-05T10:29:18Z
dc.date.issued2024
dc.descriptionResearch Articleen_US
dc.description.abstractSix undescribed cadinane sesquiterpenoids (1− 6), two undescribed guaiane sesquiterpenoids (7− 8), and an undescribed germacrane sesquiterpenoid (9) were isolated from the oleo-gum resin of Commiphora myrrha. Their structures were determined by the analysis of 1D/2D NMR and HRESIMS data, as well as quantum chemical ECD and NMR calculations. All the sesquiterpenoids were evaluated for their NO production inhibitory activity in LPS-stimulated RAW 264.7 mouse monocyte-macrophages. The results revealed that commiphone A (1) and commipholide D (7) exhibited significant inhibitory effect on NO generation with IC50 values of 18.6 ± 2.0 and 37.5 ± 1.5 μM, respectively. Furthermore, 1 and 7 dose-dependently inhibited the mRNA expression of in flammatory cytokines IL-1β, IL-6 and TNF-α induced by LPS in the RAW264.7 cells, indicating that 1 and 7 possess potent anti-inflammatory activity in vitro.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.phytochem.2024.114031
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/41405
dc.language.isoenen_US
dc.publisherPhytochemistryen_US
dc.subjectCommiphora myrrhaen_US
dc.subjectMyrrhen_US
dc.subjectBurseraceaeen_US
dc.titleUndescribed sesquiterpenoids with NO production inhibitory activity from oleo-gum resin of Commiphora myrrhaen_US
dc.typeArticleen_US

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