Undescribed sesquiterpenoids with NO production inhibitory activity from oleo-gum resin of Commiphora myrrha
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Date
2024
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Phytochemistry
Abstract
Six undescribed cadinane sesquiterpenoids (1− 6), two undescribed guaiane sesquiterpenoids (7− 8), and an
undescribed germacrane sesquiterpenoid (9) were isolated from the oleo-gum resin of Commiphora myrrha. Their
structures were determined by the analysis of 1D/2D NMR and HRESIMS data, as well as quantum chemical ECD
and NMR calculations. All the sesquiterpenoids were evaluated for their NO production inhibitory activity in
LPS-stimulated RAW 264.7 mouse monocyte-macrophages. The results revealed that commiphone A (1) and
commipholide D (7) exhibited significant inhibitory effect on NO generation with IC50 values of 18.6 ± 2.0 and
37.5 ± 1.5 μM, respectively. Furthermore, 1 and 7 dose-dependently inhibited the mRNA expression of in flammatory cytokines IL-1β, IL-6 and TNF-α induced by LPS in the RAW264.7 cells, indicating that 1 and 7
possess potent anti-inflammatory activity in vitro.
Description
Research Article
Keywords
Commiphora myrrha, Myrrh, Burseraceae