Maternal Serum Angiopoietins Levels In Pre‐Eclampsia And Pregnancy Outcomes

Abstract

Background and aims: Although the understanding of pre-eclampsia (PE) has improved, there is still insufficient knowledge on the exact etiology and pathophysiological mechanisms. Dysregulation of angiogenic factors has emerged as a significant contributing factor. Among these factors, angiopoietins (Ang1 and Ang2) have gained considerable attention due to their crucial role in regulating vascular development and endothelial function. This study explored the maternal serum levels of angiopoietins and perinatal outcomes in PE. Methods: A case-control study involving women with PE (cases) and normotensive pregnancies (controls) was conducted at the Maternity unit of the Korle‐Bu Teaching Hospital. Descriptive analysis was performed and the Mann-Whitney U test (two sided) was used to compare maternal serum levels of angiopoietins between the cases and controls. Results: We included 188 participants, comprising 94 cases (women with PE) and 94 controls (normotensive pregnancies) with an average maternal age of 29.76 ± 5.56 and 28.43 ± 5.57 years, respectively. Maternal serum levels of Ang2 were significantly lower among the PE cases compared to the normotensive controls (1.25 [0.90, 2.15] vs. 2.14 [1.18, 5.73] ng/mL, p = 0.001) but no significant difference in Ang1 levels (92.61 [80.92, 114.92] vs. 99.26 [81.76, 113.12] ng/mL, p = 0.429) was observed between the groups. The Ang1/Ang2 ratio was significantly elevated among women with PE compared to normotensive controls (74.47 [37.69, 110.59]) vs. 45.98 [16.11, 88.22] ng/mL, p = 0.014). Also, women who delivered vaginally had significantly high maternal serum levels of Ang1 compared to women who had cesarean section delivery (107.98 ± 27.79 vs. 89.02 ± 32.62 ng/mL). Conclusion: Maternal serum levels of Ang2 but not Ang1 were significantly depressed in women with PE compared to the pregnant normotensive controls. No significant associations were observed between Ang‐1, Ang‐2 levels, or the Ang‐1/ Ang‐2 ratio and pregnancy outcomes such as preterm birth, birth weight, and severity of hypertension.