Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
nature
Abstract
There is evidence that tumor immunobiology and immunotherapy response may differ
between African American and European American prostate cancer patients. Here, we
determine if men of African descent harbor a unique systemic immune-oncological signature
and measure 82 circulating proteins in almost 3000 Ghanaian, African American, and European
American men. Protein signatures for suppression of tumor immunity and chemotaxis
are elevated in men of West African ancestry. Importantly, the suppression of tumor
immunity protein signature associates with metastatic and lethal prostate cancer, pointing to
clinical importance. Moreover, two markers, pleiotrophin and TNFRSF9, predict poor disease
survival specifically among African American men. These findings indicate that immuneoncology
marker profiles differ between men of African and European descent. These differences
may contribute to the disproportionate burden of lethal prostate cancer in men of
African ancestry. The elevated peripheral suppression of tumor immunity may have important
implication for guidance of cancer therapy which could particularly benefit African
American patients.
Description
Research Article