Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection

Simple item page
dc.contributor.authorAddae, M.M.
dc.contributor.authorKomada, Y.
dc.contributor.authorZhang, X.
dc.contributor.authorSakurai, M.
dc.date.accessioned2013-04-29T13:48:24Z
dc.date.accessioned2017-10-16T11:37:39Z
dc.date.available2013-04-29T13:48:24Z
dc.date.available2017-10-16T11:37:39Z
dc.date.issued1995
dc.description.abstractThe phenotypic alterations associated with T cells during measles virus infection have been demonstrated and an attempt has been made to show programmed cell death (PCD) of T cells activated in vivo. During the acute phase of illness, activated T cells increased rapidly. Memory T cells (CD45RO+), especially CD8+ memory T cells also tend to increase. During the recovery phase, CD8+ T cells declined rapidly, and naive (CD45RA+) T cells increased in numbers. The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor (CD25) was suppressed. However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression. In addition, PCD of activated T cells from measles patients was induced in culture. After triggering of the T cell receptor-CD3 complex, cells became more susceptible to PCD. Interestingly, the addition of PMA could inhibit PCD of activated T cells. Taken together, these data suggest unresponsiveness and activation-induced cell death of T cells during the primary response to measles virus antigens, depending on the activation status of protein kinase C.en_US
dc.identifier.citationAddae, M. M., Komada, Y., Zhang, X. -., & Sakurai, M. (1995). Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection. Acta Paediatrica Japonica (Overseas Edition), 37(3), 308-314en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/7645378
dc.identifier.urihttp://197.255.68.203/handle/123456789/2746
dc.language.isoenen_US
dc.publisherActa Paediatrica Japonicaen_US
dc.subjectApoptosis/*immunologyen_US
dc.subjectCase-Control Studiesen_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectHumansen_US
dc.subjectInfanten_US
dc.subjectMeasles/*immunologyen_US
dc.subjectProtein Kinase C/blood/immunologyen_US
dc.subjectReceptors, Interleukin-2en_US
dc.subjectT-Lymphocytes/immunology/*pathologyen_US
dc.subjectTetradecanoylphorbol Acetate/pharmacologyen_US
dc.titleImmunological unresponsiveness and apoptotic cell death of T cells in measles virus infectionen_US
dc.typeArticleen_US

Files

License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.82 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
No Thumbnail Available
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Department of Haematology