Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection
dc.contributor.author | Addae, M.M. | |
dc.contributor.author | Komada, Y. | |
dc.contributor.author | Zhang, X. | |
dc.contributor.author | Sakurai, M. | |
dc.date.accessioned | 2013-04-29T13:48:24Z | |
dc.date.accessioned | 2017-10-16T11:37:39Z | |
dc.date.available | 2013-04-29T13:48:24Z | |
dc.date.available | 2017-10-16T11:37:39Z | |
dc.date.issued | 1995 | |
dc.description.abstract | The phenotypic alterations associated with T cells during measles virus infection have been demonstrated and an attempt has been made to show programmed cell death (PCD) of T cells activated in vivo. During the acute phase of illness, activated T cells increased rapidly. Memory T cells (CD45RO+), especially CD8+ memory T cells also tend to increase. During the recovery phase, CD8+ T cells declined rapidly, and naive (CD45RA+) T cells increased in numbers. The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor (CD25) was suppressed. However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression. In addition, PCD of activated T cells from measles patients was induced in culture. After triggering of the T cell receptor-CD3 complex, cells became more susceptible to PCD. Interestingly, the addition of PMA could inhibit PCD of activated T cells. Taken together, these data suggest unresponsiveness and activation-induced cell death of T cells during the primary response to measles virus antigens, depending on the activation status of protein kinase C. | en_US |
dc.identifier.citation | Addae, M. M., Komada, Y., Zhang, X. -., & Sakurai, M. (1995). Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection. Acta Paediatrica Japonica (Overseas Edition), 37(3), 308-314 | en_US |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/7645378 | |
dc.identifier.uri | http://197.255.68.203/handle/123456789/2746 | |
dc.language.iso | en | en_US |
dc.publisher | Acta Paediatrica Japonica | en_US |
dc.subject | Apoptosis/*immunology | en_US |
dc.subject | Case-Control Studies | en_US |
dc.subject | Child | en_US |
dc.subject | Child, Preschool | en_US |
dc.subject | Humans | en_US |
dc.subject | Infant | en_US |
dc.subject | Measles/*immunology | en_US |
dc.subject | Protein Kinase C/blood/immunology | en_US |
dc.subject | Receptors, Interleukin-2 | en_US |
dc.subject | T-Lymphocytes/immunology/*pathology | en_US |
dc.subject | Tetradecanoylphorbol Acetate/pharmacology | en_US |
dc.title | Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection | en_US |
dc.type | Article | en_US |