Variations in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia.

dc.contributor.authorHottor, B.
dc.contributor.authorBosio, P.
dc.contributor.authorWaugh, J.
dc.contributor.authorDiggle, P.J.
dc.contributor.authorByrne, S.
dc.contributor.authorAhenkorah, J.
dc.contributor.authorOckleford, C.D.
dc.date.accessioned2013-06-25T13:50:22Z
dc.date.accessioned2017-10-19T11:48:37Z
dc.date.available2013-06-25T13:50:22Z
dc.date.available2017-10-19T11:48:37Z
dc.date.issued2010
dc.description.abstractObjective(s): To define composition of chorionic plate and test effects of pre-eclampsia on basal plate composition. Study Design: Retrospective cohort study where distinct area fractions were measured in: healthy term chorionic plate (CP: n = 11), healthy placental basal plate (n = 11), mild pre-eclamptic basal plate (n = 10) and severe pre-eclamptic basal plate (n = 11). Results: CP lining is partly endothelial. Mean anchoring villus (AV)/acellular (NS) basal plate area ratio decreased in pre-eclampsia (p = 0.048). There was a decreasing trend with increasing disease severity. Basal plate endothelial cell proportion was not significantly lower in severe pre-eclampsia than in healthy or mild pre-eclamptics. Conclusion(s): An inverse relationship between the proportions of fibrin and anchoring villi indicates that increased basal plate fibrin deposition and reduced basal plate materno-fetal anchoring area are part of pre-eclamptic disease progression. Endothelium lining intervillous surfaces may originate from circulating maternal endothelial progenitor cellsen_US
dc.identifier.citationHottor, B., Bosio, P., Waugh, J., Diggle, P. J., Byrne, S., Ahenkorah, J., & Ockleford, C. D. (2010). Variations in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia. Placenta, 31 (5), 409-417.en_US
dc.identifier.issn01434004
dc.identifier.urihttp://197.255.68.203/handle/123456789/4062
dc.language.isoenen_US
dc.subjectAnchoring villus; Basal plate; Endothelium; Fibrinoid lining; Intervillous space; Mosaic monolayer; Pre-eclampsiaen_US
dc.subjectEMTREE drug terms: fibrinen_US
dc.subjectEMTREE medical terms: adult; article; chorion villus; clinical article; cohort analysis; controlled study; disease course; disease severity; endothelium; female; fetoplacental unit; fibrin deposition; human; human tissue; infant; male; placenta; preeclampsia; priority journal; retrospective study; stem cellen_US
dc.subjectMeSH: Adolescent; Adult; Chorionic Villi; Cohort Studies; Female; Fibrin; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Retrospective Studies; Term Birth; Young Adulten_US
dc.titleVariations in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia.en_US
dc.typeArticleen_US

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