Variations in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia.
dc.contributor.author | Hottor, B. | |
dc.contributor.author | Bosio, P. | |
dc.contributor.author | Waugh, J. | |
dc.contributor.author | Diggle, P.J. | |
dc.contributor.author | Byrne, S. | |
dc.contributor.author | Ahenkorah, J. | |
dc.contributor.author | Ockleford, C.D. | |
dc.date.accessioned | 2013-06-25T13:50:22Z | |
dc.date.accessioned | 2017-10-19T11:48:37Z | |
dc.date.available | 2013-06-25T13:50:22Z | |
dc.date.available | 2017-10-19T11:48:37Z | |
dc.date.issued | 2010 | |
dc.description.abstract | Objective(s): To define composition of chorionic plate and test effects of pre-eclampsia on basal plate composition. Study Design: Retrospective cohort study where distinct area fractions were measured in: healthy term chorionic plate (CP: n = 11), healthy placental basal plate (n = 11), mild pre-eclamptic basal plate (n = 10) and severe pre-eclamptic basal plate (n = 11). Results: CP lining is partly endothelial. Mean anchoring villus (AV)/acellular (NS) basal plate area ratio decreased in pre-eclampsia (p = 0.048). There was a decreasing trend with increasing disease severity. Basal plate endothelial cell proportion was not significantly lower in severe pre-eclampsia than in healthy or mild pre-eclamptics. Conclusion(s): An inverse relationship between the proportions of fibrin and anchoring villi indicates that increased basal plate fibrin deposition and reduced basal plate materno-fetal anchoring area are part of pre-eclamptic disease progression. Endothelium lining intervillous surfaces may originate from circulating maternal endothelial progenitor cells | en_US |
dc.identifier.citation | Hottor, B., Bosio, P., Waugh, J., Diggle, P. J., Byrne, S., Ahenkorah, J., & Ockleford, C. D. (2010). Variations in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia. Placenta, 31 (5), 409-417. | en_US |
dc.identifier.issn | 01434004 | |
dc.identifier.uri | http://197.255.68.203/handle/123456789/4062 | |
dc.language.iso | en | en_US |
dc.subject | Anchoring villus; Basal plate; Endothelium; Fibrinoid lining; Intervillous space; Mosaic monolayer; Pre-eclampsia | en_US |
dc.subject | EMTREE drug terms: fibrin | en_US |
dc.subject | EMTREE medical terms: adult; article; chorion villus; clinical article; cohort analysis; controlled study; disease course; disease severity; endothelium; female; fetoplacental unit; fibrin deposition; human; human tissue; infant; male; placenta; preeclampsia; priority journal; retrospective study; stem cell | en_US |
dc.subject | MeSH: Adolescent; Adult; Chorionic Villi; Cohort Studies; Female; Fibrin; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Retrospective Studies; Term Birth; Young Adult | en_US |
dc.title | Variations in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia. | en_US |
dc.type | Article | en_US |