Amodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic dose

dc.contributor.authorAdjei, G.O.
dc.contributor.authorGoka, B.Q.
dc.contributor.authorRodrigues, O.P.
dc.contributor.authorHoegberg, L.C.
dc.contributor.authorAlifrangis, M.
dc.contributor.authorKurtzhals, J.
dc.date.accessioned2012-05-12T17:57:58Z
dc.date.accessioned2017-10-19T11:49:05Z
dc.date.available2012-05-12T17:57:58Z
dc.date.available2017-10-19T11:49:05Z
dc.date.issued2009
dc.description.abstractA case of an acute dystonic reaction in a child presumptively treated for malaria with amodiaquine, and a case of persistent asymptomatic bradycardia in another child with mild pulmonary stenosis treated with a standard dose of amodiaquine for parasitologically confirmed uncomplicated malaria, is reported. Both subjects were homozygous for the wild type allele of cytochrome P450 2C8, the main enzyme responsible for amodiaquine metabolism. In both subjects, plasma concentrations of N-desethylamodiaquine and N-bis-desethylamodiaquine, the main metabolites of amodiaquine, were normal. No other drugs were detectable in the plasma of these two subjects after further toxicological screening. These observations, which suggest altered metabolism in the subject with an acute dystonic reaction, support the assertion that amodiaquine-associated dystonia is an idiosyncratic reaction. However, the occurrence of bradycardia after a standard dose of amodiaquine, which coincided with the time of expected peak concentrations of the active metabolite of amodiaquine, suggests a direct drug effect. These less reported adverse effects are likely to increase in parallel with the increased use of amodiaquine as a partner drug for combination therapy of malaria in Ghana. Further studies aimed at elucidating the mechanisms underlying these effects are, therefore, required.en_US
dc.identifier.urihttp://197.255.68.203/handle/123456789/1368
dc.language.isoenen_US
dc.publisherGhana Medical Journal 43(3):135-8en_US
dc.titleAmodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic doseen_US
dc.typeArticleen_US

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