Unexpected elevated alanine aminotransferase, asparte aminotransferase levels and hepatitis E virus infection among persons who work with pigs in Accra, Ghana.

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dc.contributor.authorAdjei, A.A.
dc.contributor.authorTettey, Y.
dc.contributor.authorAviyase, J.T.
dc.contributor.authorAdu-Gyamfi, C.
dc.contributor.authorMingle, J.A.
dc.contributor.authorNartey, E.T.
dc.date.accessioned2014-08-14T13:11:45Z
dc.date.available2014-08-14T13:11:45Z
dc.date.issued2010-11-22
dc.date.updated2014-08-14T13:11:54Z
dc.description.abstractAbstract Background Several studies have suggested that elevated serum alanine aminotransferase (ALT) and asparte aminotransferase (AST) may be markers of hepatitis E virus (HEV) infection. Thus, individuals with elevated ALT and AST may have ongoing subclinical infection of HEV. We estimated the prevalence of anti-HEV antibodies and serum ALT and AST levels among persons who work with pigs in Accra, Ghana. Results Three hundred and fifty- persons who work with pigs provided blood samples for unlinked anonymous testing for the presence of antibodies to HEV, ALT and AST levels. The median age of participants was 32.85 ± 11.38 years (range 15-70 years). HEV seroprevelance was 34.84%. Anti-HEV IgG was detected in 19.26% while anti-HEV IgM was detected in 15.58% of the persons who tested positive. On multivariate analysis, the independent determinants of HEV infection were, being employed on the farm for less than six months [odds ratio (OR) 8.96; 95% confidence interval (95% CI) 5.43-14.80], having piped water in the household and/or on the farm (OR 13.33; 95% CI 5.23-33.93) and consumption of alcohol (OR 4.91: 95% CI 2.65-9.10). Levels >3× the expected maximum were found for both ALT and AST among individuals who tested positive for anti-HEV IgG (ALT, 210.17 ± 11.64 U/L; AST, 127.18 ± 11.12 U/L) and anti-HEV IgM (ALT, 200.97 ± 10.76 U/L; AST, 120.00 ± 15.96 U/L). Conclusion Consistent with similar studies worldwide, the results of our studies revealed a high prevalence of HEV infection, ALT and AST values in pig handlers.
dc.description.versionPeer Reviewed
dc.identifier.urihttp://197.255.68.203/handle/123456789/5613
dc.language.rfc3066en
dc.rights.holderAndrew A Adjei et al.; licensee BioMed Central Ltd.
dc.titleUnexpected elevated alanine aminotransferase, asparte aminotransferase levels and hepatitis E virus infection among persons who work with pigs in Accra, Ghana.
dc.typeJournal Article

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