Natural cocoa inhibits maternal hypercholesterolaemia-induced atherogenesis in rabbit pups.

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dc.contributor.authorBlay, R.M.
dc.contributor.authorAdjenti, S.K.
dc.contributor.authorAdutwum-Ofosu, K.K.
dc.contributor.authorHottor, B.A.
dc.contributor.authorAhenkorah, J.
dc.contributor.authorArko-Boham, B.
dc.contributor.authorAddai, F.K.
dc.date.accessioned2019-09-30T12:14:27Z
dc.date.available2019-09-30T12:14:27Z
dc.date.issued2019-04-16
dc.descriptionResearch Articleen_US
dc.description.abstractAtherosclerosis begins during foetal development and is enhanced by maternal hypercholesterolaemia during pregnancy. This study assessed the effect of natural cocoa on atherosclerosis in offspring conceived in maternal hypercholesterolaemia. Female rabbits were fed a cholesterol-enriched diet for two weeks and hypercholesterolaemia was confirmed, after which they were crossed with normocholesterolaemic males. One group of hypercholesterolaemic mothers (HCC) received natural cocoa powder (NCP) in their drinking water, whereas the other group (HC) received only water. Histological analysis of three segments of the aorta (arch, thoracic and abdominal) from offspring of both groups was compared with a control group (NC). Intima-media thickness of the aortic arch in offspring born to hypercholesterolaemic rabbits (HC: 146 µm) was higher compared to HCC (99 µm) and control rabbits (58.5 µm). All the sections from the aortic arch of the HC group had atherosclerotic lesions while none of the sections of the aortic arch from the NC and HCC groups had lesions present. Inferentially, regular and voluntary consumption of NCP during pregnancy may inhibit aortic atherogenesis in offspring of hypercholesterolaemic mothers.en_US
dc.identifier.otherdoi: 10.5830/CVJA-2019-019.
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/32349
dc.language.isoenen_US
dc.publisherCardiovascular journal of Africaen_US
dc.relation.ispartofseries30;4
dc.subjectAtherosclerosisen_US
dc.subjectMaternalen_US
dc.subjectHypercholesterolaemiaen_US
dc.subjectIntima–mediaen_US
dc.subjectThicknessen_US
dc.subjectCocoaen_US
dc.subjectAntioxidantsen_US
dc.subjectFoetalen_US
dc.titleNatural cocoa inhibits maternal hypercholesterolaemia-induced atherogenesis in rabbit pups.en_US
dc.typeArticleen_US

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