Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

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dc.contributor.authorAhuno, S.T.
dc.contributor.authorDoebley, A-L.
dc.contributor.authorAhearn, T.U.
dc.contributor.authorYarney, J.
dc.contributor.authorTitiloye, N.
dc.contributor.authorHamel, N.
dc.contributor.authorAdjei, E.
dc.contributor.authorClegg-Lamptey, J-N.
dc.contributor.authorEdusei, L.
dc.contributor.authorAwuah, B.
dc.contributor.authorSong, X.
dc.contributor.authorVanderpuye, V.
dc.contributor.authorAbubakar, M.
dc.contributor.authorDuggan, M.
dc.contributor.authorStover, D.G.
dc.contributor.authorNyarko, K.
dc.contributor.authorBartlett, J.M.S.
dc.contributor.authorAitpillah, F.
dc.contributor.authorAnsong, D.
dc.contributor.authorGardner, K.L.
dc.contributor.authorBoateng, F.A.
dc.contributor.authorBowcock, A.M.
dc.contributor.authorCaldas, C.
dc.contributor.authorFoulkes, W.D.
dc.contributor.authorWiafe, S.
dc.contributor.authorWiafe-Addai, B.
dc.contributor.authorGarcia-Closas, M.
dc.contributor.authorKwarteng, A.
dc.contributor.authorHa, G.
dc.contributor.authorFigueroa, J.D.
dc.contributor.authorPolak, P.
dc.contributor.authorGhana Breast Health Study Team
dc.date.accessioned2021-11-18T10:20:27Z
dc.date.available2021-11-18T10:20:27Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractCirculating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub- Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.en_US
dc.identifier.otherhttps://doi.org/10.1038/s41698-021-00219-7.
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37162
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjecttumoren_US
dc.subjectDNAen_US
dc.subjectbreast canceren_US
dc.subjectAfricaen_US
dc.titleCirculating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africaen_US
dc.typeArticleen_US

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