Maternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana: Follow-up of a Randomized Trial
dc.contributor.author | Kumordzie, S.M. | |
dc.contributor.author | Adu-Afarwuah, S. | |
dc.contributor.author | Young, R.R. | |
dc.contributor.author | Oaks, B.M. | |
dc.contributor.author | Tamakloe, S.M. | |
dc.contributor.author | Ocansey, M.E. | |
dc.contributor.author | Okronipa, H. | |
dc.contributor.author | Prado, E.L. | |
dc.contributor.author | Dewey, K.G. | |
dc.date.accessioned | 2019-05-20T15:58:15Z | |
dc.date.available | 2019-05-20T15:58:15Z | |
dc.date.issued | 2019-03 | |
dc.description.abstract | Background: In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, prenatal small-quantity lipid-based nutrient supplements (LNSs) had a positive effect on birth weight. Birth weight may be inversely related to blood pressure (BP) later in life. Objectives: We examined the effect of the intervention on BP at 4-6 y of age, and maternal and child factors related to BP. Methods: The iLiNS-DYAD-Ghana study was a partially double-blind, randomized controlled trial which assigned women (n = 1320) ≤20 weeks of gestation to daily supplementation with: 1) iron and folic acid during pregnancy and 200 mg Ca for 6 mo postpartum , 2) multiple micronutrients during pregnancy and postpartum, or 3) LNSs during pregnancy and postpartum plus LNSs for infants from 6 to 18 mo of age. At 4-6 y of age (n = 858, 70% of live births), we compared BP, a secondary outcome, between non-LNS and LNS groups and examined whether BP was related to several factors including maternal BP, child weight-for-age z score (WAZ), and physical activity. Results: Non-LNS and LNS groups did not differ in systolic (99.2 ± 0.4 compared with 98.5 ± 0.6 mm Hg; P = 0.317) or diastolic (60.1 ± 0.3 compared with 60.0 ± 0.4 mm Hg; P = 0.805) BP, or prevalence of high BP (systolic or diastolic BP ≥90th percentile of the US National Heart, Lung, and Blood Institute reference: 31% compared with 28%; P = 0.251). BP at 4-6 y of age was positively related to birth weight; this relation was largely mediated through concurrent WAZ in a path model. Concurrent WAZ and maternal BP were the factors most strongly related to child BP. Conclusions: Despite greater birth weight in the LNS group, there was no intervention group difference in BP at 4-6 y. In this preschool population at high risk of adult hypertension based on BP at 4-6 y, high maternal BP and child WAZ were key factors related to BP. This trial was registered at clinicaltrials.gov as NCT00970866. | en_US |
dc.identifier.other | DOI: 10.1093/jn/nxy285 | |
dc.identifier.other | Vol.149(3): pp 522-531 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/30122 | |
dc.language.iso | en | en_US |
dc.publisher | Journal of Nutrition | en_US |
dc.subject | Supplementation | en_US |
dc.subject | Blood pressure | en_US |
dc.subject | Lipid-based nutrient supplements | en_US |
dc.subject | Ghanaian children | en_US |
dc.subject | Prenatal | en_US |
dc.subject | Infant nutrition | en_US |
dc.title | Maternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana: Follow-up of a Randomized Trial | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Maternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana Follow-up of a Randomized Trial.pdf
- Size:
- 328.1 KB
- Format:
- Adobe Portable Document Format
- Description:
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.6 KB
- Format:
- Item-specific license agreed upon to submission
- Description: