Maternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana: Follow-up of a Randomized Trial

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dc.contributor.authorKumordzie, S.M.
dc.contributor.authorAdu-Afarwuah, S.
dc.contributor.authorYoung, R.R.
dc.contributor.authorOaks, B.M.
dc.contributor.authorTamakloe, S.M.
dc.contributor.authorOcansey, M.E.
dc.contributor.authorOkronipa, H.
dc.contributor.authorPrado, E.L.
dc.contributor.authorDewey, K.G.
dc.date.accessioned2019-05-20T15:58:15Z
dc.date.available2019-05-20T15:58:15Z
dc.date.issued2019-03
dc.description.abstractBackground: In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, prenatal small-quantity lipid-based nutrient supplements (LNSs) had a positive effect on birth weight. Birth weight may be inversely related to blood pressure (BP) later in life. Objectives: We examined the effect of the intervention on BP at 4-6 y of age, and maternal and child factors related to BP. Methods: The iLiNS-DYAD-Ghana study was a partially double-blind, randomized controlled trial which assigned women (n = 1320) ≤20 weeks of gestation to daily supplementation with: 1) iron and folic acid during pregnancy and 200 mg Ca for 6 mo postpartum , 2) multiple micronutrients during pregnancy and postpartum, or 3) LNSs during pregnancy and postpartum plus LNSs for infants from 6 to 18 mo of age. At 4-6 y of age (n = 858, 70% of live births), we compared BP, a secondary outcome, between non-LNS and LNS groups and examined whether BP was related to several factors including maternal BP, child weight-for-age z score (WAZ), and physical activity. Results: Non-LNS and LNS groups did not differ in systolic (99.2 ± 0.4 compared with 98.5 ± 0.6 mm Hg; P = 0.317) or diastolic (60.1 ± 0.3 compared with 60.0 ± 0.4 mm Hg; P = 0.805) BP, or prevalence of high BP (systolic or diastolic BP ≥90th percentile of the US National Heart, Lung, and Blood Institute reference: 31% compared with 28%; P = 0.251). BP at 4-6 y of age was positively related to birth weight; this relation was largely mediated through concurrent WAZ in a path model. Concurrent WAZ and maternal BP were the factors most strongly related to child BP. Conclusions: Despite greater birth weight in the LNS group, there was no intervention group difference in BP at 4-6 y. In this preschool population at high risk of adult hypertension based on BP at 4-6 y, high maternal BP and child WAZ were key factors related to BP. This trial was registered at clinicaltrials.gov as NCT00970866.en_US
dc.identifier.otherDOI: 10.1093/jn/nxy285
dc.identifier.otherVol.149(3): pp 522-531
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30122
dc.language.isoenen_US
dc.publisherJournal of Nutritionen_US
dc.subjectSupplementationen_US
dc.subjectBlood pressureen_US
dc.subjectLipid-based nutrient supplementsen_US
dc.subjectGhanaian childrenen_US
dc.subjectPrenatalen_US
dc.subjectInfant nutritionen_US
dc.titleMaternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana: Follow-up of a Randomized Trialen_US
dc.typeArticleen_US

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