Acquisition of IGG to ICAM-1-Binding DBLΒ Domains in the plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between groups A, B, and C

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dc.contributor.authorEcklu-Mensah, G.
dc.contributor.authorOlsen, R.W.
dc.contributor.authorBengtsson, A.
dc.contributor.authorOfori, M.F.
dc.contributor.authorKusi, K.A.
dc.contributor.authorKoram, K.A.
dc.contributor.authorHviid, L.
dc.contributor.authorAdams, Y.
dc.contributor.authorJensen, A.T.R.
dc.date.accessioned2019-11-27T12:40:11Z
dc.date.available2019-11-27T12:40:11Z
dc.date.issued2019-09-19
dc.descriptionResearch Articleen_US
dc.description.abstractPlasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The kinetics of acquisition of IgG to group B and C PfEMP1 proteins binding ICAM-1 is unclear and was studied here. Gene sequences encoding group B and C PfEMP1 with DBL domains known to bind ICAM-1 were used to identify additional binders. Levels of IgG specific for DBL domains from group A, B, and C PfEMP1 binding or not binding ICAM-1 were measured in plasma from Ghanaian children with or without malaria. Seven new ICAM-1-binding DBL domains from group B and C PfEMP1 were identified. Healthy children had higher levels of IgG specific for ICAM-1-binding DBL domains from group A than from groups B and C. However, the opposite pattern was found in children with malaria, particularly among young patients. Acquisition of IgG specific for DBL domains binding ICAM-1 differs between PfEMP1 groups.en_US
dc.description.sponsorshipNovo Nordisk Fonden (NNF16OC0022298), Lundbeckfonden (R180-2014-3098), the Danish Council for Independent Research (4004- 00032), the Consultative Committee for Development Research (12-081RH), and the Division of Microbiology and Immunology Diseases, NIAID, NIH (contract number HHSN266200400016C).en_US
dc.identifier.citationOlsen RW, Ecklu-Mensah G, Bengtsson A, Ofori MF, Kusi KA, Koram KA, Hviid L, Adams Y, Jensen ATR. 2019. Acquisition of IgG to ICAM-1-binding DBLβ domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between groups A, B, and C. Infect Immun 87:e00224-19. https://doi.org/10.1128/IAI.00224-19.en_US
dc.identifier.otherhttps://doi.org/10.1128/IAI.00224-19.
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/33870
dc.language.isoenen_US
dc.publisherInfection and Immunityen_US
dc.relation.ispartofseries87;10
dc.subjectPfEMP1en_US
dc.subjectPlasmodium falciparumen_US
dc.subjectantibodiesen_US
dc.subjectimmunityen_US
dc.subjectmalariaen_US
dc.titleAcquisition of IGG to ICAM-1-Binding DBLΒ Domains in the plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between groups A, B, and Cen_US
dc.typeArticleen_US

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