Acquisition of IGG to ICAM-1-Binding DBLΒ Domains in the plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between groups A, B, and C
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Date
2019-09-19
Journal Title
Journal ISSN
Volume Title
Publisher
Infection and Immunity
Abstract
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important
malaria virulence factor. The protein family can be divided into clinically relevant
subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor
and have been associated with cerebral malaria in children. IgG to these PfEMP1
proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The
kinetics of acquisition of IgG to group B and C PfEMP1 proteins binding ICAM-1 is unclear
and was studied here. Gene sequences encoding group B and C PfEMP1 with
DBL domains known to bind ICAM-1 were used to identify additional binders. Levels of
IgG specific for DBL domains from group A, B, and C PfEMP1 binding or not binding
ICAM-1 were measured in plasma from Ghanaian children with or without malaria.
Seven new ICAM-1-binding DBL domains from group B and C PfEMP1 were identified.
Healthy children had higher levels of IgG specific for ICAM-1-binding DBL domains
from group A than from groups B and C. However, the opposite pattern was found in
children with malaria, particularly among young patients. Acquisition of IgG specific for
DBL domains binding ICAM-1 differs between PfEMP1 groups.
Description
Research Article
Keywords
PfEMP1, Plasmodium falciparum, antibodies, immunity, malaria
Citation
Olsen RW, Ecklu-Mensah G, Bengtsson A, Ofori MF, Kusi KA, Koram KA, Hviid L, Adams Y, Jensen ATR. 2019. Acquisition of IgG to ICAM-1-binding DBLβ domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between groups A, B, and C. Infect Immun 87:e00224-19. https://doi.org/10.1128/IAI.00224-19.