Vasodilatory constituents of essential oil from Nardostachys jatamansi DC.: Virtual screening, experimental validation and the potential molecular mechanisms
Date
2023
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Arabian Journal of Chemistry
Abstract
Abstract Recent studies have demonstrated that the essential oil of Nardostachys jatamansi
(EONJ) has potential health benefits, such as reducing blood pressure, protecting the heart, and
relaxing blood vessels. However, the active constituents and the underlying molecular mechanisms
are still unclear. In this study, we utilized GC–MS to identify the chemical constituents of EONJ
and tested its vasodilatory effects on constricted isolated thoracic aorta rings from mice. We then
combined network pharmacology with spectrum-effect relationship approaches to select potential
marker ingredients and uncover the possible vascular protective mechanism of EONJ. Among
the four main chemicals screened in this work, b-maaliene and patchouli alcohol exhibited varying
levels of vasodilatory effects on isolated, constricted thoracic aortic rings. Bioinformatics and net work pharmacology analyses revealed that EONJ’s primary biological regulation targets were
NOS3 and PTGS2. Moreover, EONJ may exert its vasodilatory effects by modulating lipid and therosclerosis and the PI3K-AKT signaling pathways. This study provides the first report on the
vasodilatory effects and possible molecular mechanisms of EONJ. The findings may serve as a ref erence for quality evaluation, identification of bioactive markers, and future applications of EONJ
in the prevention and treatment of vascular and cardiac diseases.
Description
Research Article
Keywords
Nardostachys jatamansi DC, Essential oil, Vasodilatation