Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula
dc.contributor.author | Annan, K. | |
dc.contributor.author | Ekuadzi, E. | |
dc.contributor.author | Asare, C. | |
dc.contributor.author | Sarpong, K. | |
dc.contributor.author | Pistorius, D. | |
dc.contributor.author | Oberer, L. | |
dc.contributor.author | Gyan, B.A. | |
dc.contributor.author | Ofori, M. | |
dc.date.accessioned | 2018-11-05T12:28:15Z | |
dc.date.available | 2018-11-05T12:28:15Z | |
dc.date.issued | 2014-11 | |
dc.description.abstract | Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM. © 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. | en_US |
dc.identifier.other | https://doi.org/10.1016/j.phytol.2014.10.028 | |
dc.identifier.other | Volume 11,Pages 28-31 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/25275 | |
dc.language.iso | en | en_US |
dc.publisher | Phytochemistry Letters | en_US |
dc.subject | Antiplasmodial | en_US |
dc.subject | Bisclerodane imide | en_US |
dc.subject | Clerodane | en_US |
dc.subject | Diterpenes | en_US |
dc.subject | Polyalthia longifolia | en_US |
dc.title | Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula | en_US |
dc.type | Article | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.6 KB
- Format:
- Item-specific license agreed upon to submission
- Description: