Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula

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dc.contributor.authorAnnan, K.
dc.contributor.authorEkuadzi, E.
dc.contributor.authorAsare, C.
dc.contributor.authorSarpong, K.
dc.contributor.authorPistorius, D.
dc.contributor.authorOberer, L.
dc.contributor.authorGyan, B.A.
dc.contributor.authorOfori, M.
dc.date.accessioned2018-11-05T12:28:15Z
dc.date.available2018-11-05T12:28:15Z
dc.date.issued2014-11
dc.description.abstractAlong with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM. © 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.phytol.2014.10.028
dc.identifier.otherVolume 11,Pages 28-31
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/25275
dc.language.isoenen_US
dc.publisherPhytochemistry Lettersen_US
dc.subjectAntiplasmodialen_US
dc.subjectBisclerodane imideen_US
dc.subjectClerodaneen_US
dc.subjectDiterpenesen_US
dc.subjectPolyalthia longifoliaen_US
dc.titleAntiplasmodial constituents from the stem bark of Polyalthia longifolia var pendulaen_US
dc.typeArticleen_US

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