Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula
No Thumbnail Available
Date
2014-11
Journal Title
Journal ISSN
Volume Title
Publisher
Phytochemistry Letters
Abstract
Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM. © 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Description
Keywords
Antiplasmodial, Bisclerodane imide, Clerodane, Diterpenes, Polyalthia longifolia