Benign disorders of the prostate: A histopathological study

dc.contributor.authorAnim, J.T.
dc.contributor.authorEbrahim, B.H.
dc.contributor.authorSathar, S.A.
dc.date.accessioned2013-06-24T11:40:03Z
dc.date.accessioned2017-10-19T12:45:32Z
dc.date.available2013-06-24T11:40:03Z
dc.date.available2017-10-19T12:45:32Z
dc.date.issued1998
dc.description.abstractAlthough the medical literature contains adequate accounts of the pathophysiology of various benign prostatic disorders, it is often necessary to revisit these lesions, to reexamine the relationships between known benign lesions and more sinister, malignant disorders, in the light of new advances in our understanding of the processes. We carried out a histopathological review of prostatic surgical pathology material seen over a seven-year period in our hospital. Our findings show that benign enlargement of the prostate or benign prostatic hyperplasia (BPH) is initially fibromuscular in many cases, becoming glandulostromal with advancing age. While we found no relationship between prostatitis and age, individual gland necrosis tended to occur relatively early and correlated well with stromal repair, which we believe forms the basis of fibromuscular hyperplasia. Epithelial hyperplasia may result from glandular regeneration, and basal cell hyperplasia, papillary hyperplasia and cribriform hyperplasia all showed significant correlation with prostatic intraepithelial neoplasia (PIN). On the other hand, only cribriform hyperplasia showed correlation with atypical adenomatous hyperplasia (AAH), and also demonstrated an increase in incidence with advancing age. Our findings underline the positive relationships between benign events such as glandular necrosis with repair and epithelial hyperplasia, which may itself predispose to recognized premalignant lesions such as PIN.en_US
dc.identifier.citationAnim, J. T., Ebrahim, B. H., & Sathar, S. A. (1998). Benign disorders of the prostate: A histopathological study. Annals of Saudi Medicine, 18(1), 22-27.en_US
dc.identifier.issn02564947
dc.identifier.urihttp://197.255.68.203/handle/123456789/3980
dc.language.isoenen_US
dc.publisherAnnals of Saudi Medicineen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectArticleen_US
dc.subjectBasal cellen_US
dc.subjectCell hyperplasiaen_US
dc.subjectFibromuscular dysplasiaen_US
dc.subjectHistopathologyen_US
dc.subjectHumanen_US
dc.subjectHuman tissueen_US
dc.subjectMajor clinical studyen_US
dc.subjectMaleen_US
dc.subjectPathophysiologyen_US
dc.subjectPriority journalen_US
dc.subjectProstate hypertrophyen_US
dc.subjectProstatic intraepithelial neoplasiaen_US
dc.subjectProstatitisen_US
dc.subjectTissue regenerationen_US
dc.titleBenign disorders of the prostate: A histopathological studyen_US
dc.typeArticleen_US

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