Prophylaxis against post-appendicectomy wound infection. A controlled clinical trial of intravenous (i.v.) metronidazole versus i.v. metronidazole-ampicillin-gentamicin.

dc.contributor.authorGrant, C.
dc.contributor.authorTwum-Danso, K.
dc.contributor.authorAL-Awami, M.S.
dc.contributor.authorAL-Breiki, H.
dc.contributor.authorWosornu, L.
dc.date.accessioned2013-06-14T14:27:14Z
dc.date.accessioned2017-10-19T12:11:50Z
dc.date.available2013-06-14T14:27:14Z
dc.date.available2017-10-19T12:11:50Z
dc.date.issued1989-04
dc.description.abstractA controlled clinical trial has been conducted on three doses of intravenous (I.V.) metronidazole alone and of I.V. metronidazole-gentamicin-ampicillin combined in wound infection following appendicectomy for non-perforated appendicitis. Of the 205 patients entered, 154 were evaluable. There were 118 males and 36 females (3.3:1), their mean age was 24 +/- 9.8 years, and mean Quetelet index was 23 +/- 5. The two groups were comparable in terms of seven potential risk factors: age, sex, Quetelet index, mean duration of operation, wound contamination, nasal carriage of S. aureus, and operating surgeon's rank. The over-all wound infection rate was 10.4%. There were two delayed infections in each treatment group. We found no difference between the two treatment groups in terms of wound infection and delayed wound infection. No adverse drug reaction was seen. We conclude that the two regimens are equally convenient, safe, effective, and reliable. But, metronidazole alone is the less expensive of the two.en_US
dc.identifier.issnPMID: 2666335
dc.identifier.urihttp://197.255.68.203/handle/123456789/3167
dc.publisherPubMeden_US
dc.titleProphylaxis against post-appendicectomy wound infection. A controlled clinical trial of intravenous (i.v.) metronidazole versus i.v. metronidazole-ampicillin-gentamicin.en_US
dc.typeArticleen_US

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