Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia

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dc.contributor.authorAbabio, G.K.
dc.contributor.authorAdu-Bonsaffoh, K.
dc.contributor.authorAbindau, E.
dc.contributor.authorNarh, G.
dc.contributor.authorTetteh, D.
dc.contributor.authorBotchway, F.
dc.contributor.authorMorvey, D.
dc.contributor.authorNeequaye, J.
dc.contributor.authorQuaye, I.K.
dc.date.accessioned2019-12-13T15:18:46Z
dc.date.available2019-12-13T15:18:46Z
dc.date.issued2019-11-27
dc.descriptionResearch Articleen_US
dc.description.abstractBackground: Factor V Leiden polymorphism is a well-recognized genetic factor in the etiology of preeclampsia. Considering that Ghana is recording high incidence of preeclampsia, we examined if factor V Leiden is a contributory factor to its development and pregnancy outcomes. Methods: STROBE consensus checklist was adopted to recruit eighty-one (81) consenting subjects after ethical clearance. Subjects were followed up till delivery to obtain outcomes of PE. Routine blood chemistry and proteinuria were done on all samples. Factor V Leiden was characterized by polymerase chain reaction and restriction fragment length polymorphism (RFLP). The data was captured as protected health information (PHI) and analyzed with SPSS version 22. Results: Overall allelic frequencies found in FVL exon 10 were 0.67 and 0.33 for G and A alleles respectively. The FVL mutation was more in PE and hypertensive patients. Increased white blood cells, increased uric acid and a three – fold increment of AST / ALT ratio was observed in PE cases when stratified by FVL exons (exon 8 and 10). Significant differences were also observed between FVL and age, systolic blood pressure (SBP), diastolic blood pressure (DBP), liver enzymes, white blood cells (wbc), hemoglobin levels. Conclusion: FVL mutation allele frequency was 0.33, a first report. The mutation was associated with increased uric acid, liver enzymes and blood cell indices suggestive of acute inflammation.en_US
dc.description.sponsorshipORID, University of Ghana, Legon and an additional soft grant from QI.en_US
dc.identifier.otherhttps://doi.org/10.1186/s12881-019-0924-6
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/34184
dc.language.isoenen_US
dc.publisherBMC Medical Geneticsen_US
dc.relation.ispartofseries20;2019
dc.subjectFactor Ven_US
dc.subjectLeidenen_US
dc.subjectPreeclampsiaen_US
dc.subjectPolymerase chain reactionen_US
dc.subjectRestrictionen_US
dc.titleEffects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsiaen_US
dc.typeArticleen_US

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