Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia
dc.contributor.author | Ababio, G.K. | |
dc.contributor.author | Adu-Bonsaffoh, K. | |
dc.contributor.author | Abindau, E. | |
dc.contributor.author | Narh, G. | |
dc.contributor.author | Tetteh, D. | |
dc.contributor.author | Botchway, F. | |
dc.contributor.author | Morvey, D. | |
dc.contributor.author | Neequaye, J. | |
dc.contributor.author | Quaye, I.K. | |
dc.date.accessioned | 2019-12-13T15:18:46Z | |
dc.date.available | 2019-12-13T15:18:46Z | |
dc.date.issued | 2019-11-27 | |
dc.description | Research Article | en_US |
dc.description.abstract | Background: Factor V Leiden polymorphism is a well-recognized genetic factor in the etiology of preeclampsia. Considering that Ghana is recording high incidence of preeclampsia, we examined if factor V Leiden is a contributory factor to its development and pregnancy outcomes. Methods: STROBE consensus checklist was adopted to recruit eighty-one (81) consenting subjects after ethical clearance. Subjects were followed up till delivery to obtain outcomes of PE. Routine blood chemistry and proteinuria were done on all samples. Factor V Leiden was characterized by polymerase chain reaction and restriction fragment length polymorphism (RFLP). The data was captured as protected health information (PHI) and analyzed with SPSS version 22. Results: Overall allelic frequencies found in FVL exon 10 were 0.67 and 0.33 for G and A alleles respectively. The FVL mutation was more in PE and hypertensive patients. Increased white blood cells, increased uric acid and a three – fold increment of AST / ALT ratio was observed in PE cases when stratified by FVL exons (exon 8 and 10). Significant differences were also observed between FVL and age, systolic blood pressure (SBP), diastolic blood pressure (DBP), liver enzymes, white blood cells (wbc), hemoglobin levels. Conclusion: FVL mutation allele frequency was 0.33, a first report. The mutation was associated with increased uric acid, liver enzymes and blood cell indices suggestive of acute inflammation. | en_US |
dc.description.sponsorship | ORID, University of Ghana, Legon and an additional soft grant from QI. | en_US |
dc.identifier.other | https://doi.org/10.1186/s12881-019-0924-6 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/34184 | |
dc.language.iso | en | en_US |
dc.publisher | BMC Medical Genetics | en_US |
dc.relation.ispartofseries | 20;2019 | |
dc.subject | Factor V | en_US |
dc.subject | Leiden | en_US |
dc.subject | Preeclampsia | en_US |
dc.subject | Polymerase chain reaction | en_US |
dc.subject | Restriction | en_US |
dc.title | Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia | en_US |
dc.type | Article | en_US |
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